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本文引用的文献

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Extracorporeal shockwave therapy: A systematic review of its use in fracture management.体外冲击波疗法:关于其在骨折治疗中应用的系统评价
Indian J Orthop. 2009 Apr;43(2):161-7. doi: 10.4103/0019-5413.50851.
2
Extracorporeal shock wave-mediated changes in proliferation, differentiation, and gene expression of human osteoblasts.体外冲击波介导的人成骨细胞增殖、分化及基因表达的变化
J Trauma. 2008 Dec;65(6):1402-10. doi: 10.1097/TA.0b013e318173e7c2.
3
Biological effects of extracorporeal shockwave in bone healing: a study in rabbits.体外冲击波对骨愈合的生物学效应:一项在兔身上的研究。
Arch Orthop Trauma Surg. 2008 Aug;128(8):879-84. doi: 10.1007/s00402-008-0663-1. Epub 2008 Jun 17.
4
Prevalence of long-bone non-unions.长骨骨不连的患病率。
Injury. 2007 May;38 Suppl 2:S3-9. doi: 10.1016/s0020-1383(07)80003-9.
5
Effects of extracorporeal shock wave therapy on bone.体外冲击波疗法对骨骼的影响。
Vet Surg. 2004 Jan-Feb;33(1):40-8. doi: 10.1111/j.1532-950x.2004.04013.x.
6
Influence of extracorporeal shock-wave application on normal bone in an animal model in vivo. Scintigraphy, MRI and histopathology.体内动物模型中体外冲击波应用对正常骨骼的影响。闪烁扫描、磁共振成像和组织病理学。
J Bone Joint Surg Br. 2002 May;84(4):592-9. doi: 10.1302/0301-620x.84b4.11621.
7
Scintigraphic evaluation of tibial shaft fracture healing.胫骨干骨折愈合的闪烁扫描评估。
Injury. 2000 Jan;31(1):51-4. doi: 10.1016/s0020-1383(99)00234-x.
8
Scintimetric evaluation of remodeling after bone fractures in man.人体骨折后重塑的闪烁扫描评估。
J Nucl Med. 1993 Sep;34(9):1403-9.
9
Can serial scintigraphic studies detect delayed fracture union in man?连续闪烁扫描研究能否检测出人类骨折延迟愈合?
Clin Orthop Relat Res. 1981 Oct(160):227-32.
10
Prediction of fracture healing in the tibia by quantitative radionuclide imaging.通过定量放射性核素成像预测胫骨骨折愈合情况。
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骨闪烁显像(BS)在体外冲击波治疗(ESWT)诱导骨愈合中的预测作用。

Predictive role of scintigraphy (BS) in bone union induction using extracorporeal shock wave treatment (ESWT).

作者信息

Czarnowska-Cubała Monika, Gwoździewicz Katarzyna, Studniarek Michał, Lasek Jerzy

机构信息

Department of Radiology, Medical University of Gdańsk, 80-952 Gdańsk, Poland.

Department of Trauma Surgery, Medical University of Gdańsk, 80-952 Gdańsk, Poland.

出版信息

J Orthop. 2013 May 29;10(2):70-3. doi: 10.1016/j.jor.2013.04.005. eCollection 2013.

DOI:10.1016/j.jor.2013.04.005
PMID:24403753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3772561/
Abstract

AIMS

Pseudoarthrosis and delayed bone union are the main complications in the healing process of long bones fractures. The surgical intervention is currently the treatment of choice, but there is a number of non-operative interventions are being developed, such as extracorporeal shock wave therapy (ESWT). There is a range of issues related to the proper qualification, monitoring, and outcome assessment measures. Bone scintigraphy (BS) exclusively allows the assessment of the bone turnover dynamics in non-invasive, semi quantitative method.

METHODS

The study group comprised of 31 subjects with bone healing complications. The study population was divided in two subgroups as related to the treatment outcome assessed 24 weeks after ESWT procedure. Group I (n = 19) included the cases with no complete bone union. Group II (n = 12) covered the subjects with complete bone union. BS was performed right before ESWT and 2 weeks after the procedure.

RESULTS

Increase of agent uptake after ESWT procedure was noted in both groups which proves that ESWT increases bone metabolism dynamics in most patients. Significantly higher uptake increase was noted in patients with complete bone union. In patients with unsuccessful treatment the agent uptake before ESWT was much higher. Two weeks after ESWT procedure BS reveals an increase in bone metabolism in the area of complicated fracture proving positive reaction of bony tissue on mechanical waves.

CONCLUSION

Scintigraphy may facilitate qualification patients with bone union disorders for further mode of treatment. One can suppose that positive bone reaction is achievable only in bone where the metabolism is lowered.

摘要

目的

假关节和骨延迟愈合是长骨骨折愈合过程中的主要并发症。目前手术干预是首选治疗方法,但也正在开发一些非手术干预措施,如体外冲击波疗法(ESWT)。在适当的资格认定、监测和结果评估措施方面存在一系列问题。骨闪烁显像(BS)仅允许以非侵入性的半定量方法评估骨转换动态。

方法

研究组由31例有骨愈合并发症的受试者组成。根据ESWT治疗后24周评估的治疗结果,将研究人群分为两个亚组。第一组(n = 19)包括未完全骨愈合的病例。第二组(n = 12)涵盖骨完全愈合的受试者。在ESWT治疗前和治疗后2周进行骨闪烁显像。

结果

两组在ESWT治疗后均观察到放射性药物摄取增加,这证明ESWT在大多数患者中增加了骨代谢动态。骨完全愈合的患者放射性药物摄取增加明显更高。治疗未成功的患者在ESWT治疗前放射性药物摄取要高得多。ESWT治疗后2周,骨闪烁显像显示复杂骨折区域骨代谢增加,证明骨组织对机械波有阳性反应。

结论

骨闪烁显像可能有助于对骨愈合障碍患者进行进一步治疗方式的资格认定。可以推测,只有在代谢降低的骨中才能实现阳性骨反应。