Czarnowska-Cubała Monika, Gwoździewicz Katarzyna, Studniarek Michał, Lasek Jerzy
Department of Radiology, Medical University of Gdańsk, 80-952 Gdańsk, Poland.
Department of Trauma Surgery, Medical University of Gdańsk, 80-952 Gdańsk, Poland.
J Orthop. 2013 May 29;10(2):70-3. doi: 10.1016/j.jor.2013.04.005. eCollection 2013.
Pseudoarthrosis and delayed bone union are the main complications in the healing process of long bones fractures. The surgical intervention is currently the treatment of choice, but there is a number of non-operative interventions are being developed, such as extracorporeal shock wave therapy (ESWT). There is a range of issues related to the proper qualification, monitoring, and outcome assessment measures. Bone scintigraphy (BS) exclusively allows the assessment of the bone turnover dynamics in non-invasive, semi quantitative method.
The study group comprised of 31 subjects with bone healing complications. The study population was divided in two subgroups as related to the treatment outcome assessed 24 weeks after ESWT procedure. Group I (n = 19) included the cases with no complete bone union. Group II (n = 12) covered the subjects with complete bone union. BS was performed right before ESWT and 2 weeks after the procedure.
Increase of agent uptake after ESWT procedure was noted in both groups which proves that ESWT increases bone metabolism dynamics in most patients. Significantly higher uptake increase was noted in patients with complete bone union. In patients with unsuccessful treatment the agent uptake before ESWT was much higher. Two weeks after ESWT procedure BS reveals an increase in bone metabolism in the area of complicated fracture proving positive reaction of bony tissue on mechanical waves.
Scintigraphy may facilitate qualification patients with bone union disorders for further mode of treatment. One can suppose that positive bone reaction is achievable only in bone where the metabolism is lowered.
假关节和骨延迟愈合是长骨骨折愈合过程中的主要并发症。目前手术干预是首选治疗方法,但也正在开发一些非手术干预措施,如体外冲击波疗法(ESWT)。在适当的资格认定、监测和结果评估措施方面存在一系列问题。骨闪烁显像(BS)仅允许以非侵入性的半定量方法评估骨转换动态。
研究组由31例有骨愈合并发症的受试者组成。根据ESWT治疗后24周评估的治疗结果,将研究人群分为两个亚组。第一组(n = 19)包括未完全骨愈合的病例。第二组(n = 12)涵盖骨完全愈合的受试者。在ESWT治疗前和治疗后2周进行骨闪烁显像。
两组在ESWT治疗后均观察到放射性药物摄取增加,这证明ESWT在大多数患者中增加了骨代谢动态。骨完全愈合的患者放射性药物摄取增加明显更高。治疗未成功的患者在ESWT治疗前放射性药物摄取要高得多。ESWT治疗后2周,骨闪烁显像显示复杂骨折区域骨代谢增加,证明骨组织对机械波有阳性反应。
骨闪烁显像可能有助于对骨愈合障碍患者进行进一步治疗方式的资格认定。可以推测,只有在代谢降低的骨中才能实现阳性骨反应。