间充质干细胞的免疫调节特性和位点特异性亲和力：细胞治疗的希望
Immunomodulatory nature and site specific affinity of mesenchymal stem cells: a hope in cell therapy.
作者信息
Lotfinegad Parisa, Shamsasenjan Karim, Movassaghpour Aliakbar, Majidi Jafar, Baradaran Behzad
机构信息
Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tabriz, Iran.
出版信息
Adv Pharm Bull. 2014;4(1):5-13. doi: 10.5681/apb.2014.002. Epub 2013 Dec 23.
Abstract
Immunosuppressive ability of mesenchymal stem cells (MSCs), their differentiation properties to various specialized tissue types, ease of in vitro and in vivo expansion and specific migration capacity, make them to be tested in different clinical trials for the treatment of various diseases. The immunomodulatory effects of MSCs are less identified which probably has high clinically significance. The clinical trials based on primary research will cause better understanding the ability of MSCs in immunomodulatory applications and site specific migration in the optimization of therapy. So, this review focus on MSCs functional role in modulating immune responses, their ability in homing to tumor, their potency as delivery vehicle and their medical importance.
摘要
间充质干细胞（MSCs）的免疫抑制能力、它们向各种特定组织类型的分化特性、易于在体外和体内扩增以及特定的迁移能力，使其在治疗各种疾病的不同临床试验中接受检验。MSCs的免疫调节作用尚未完全明确，这可能具有很高的临床意义。基于初步研究的临床试验将有助于更好地了解MSCs在免疫调节应用中的能力以及在优化治疗中特定部位迁移的能力。因此，本综述重点关注MSCs在调节免疫反应中的功能作用、它们归巢至肿瘤的能力、作为递送载体的潜力以及它们的医学重要性。
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