Morioka Tomoaki, Emoto Masanori, Yamazaki Yuko, Kawano Naoya, Imamura Satoshi, Numaguchi Ryutaro, Urata Hiromi, Motoyama Koka, Mori Katsuhito, Fukumoto Shinya, Koyama Hidenori, Shoji Tetsuo, Inaba Masaaki
Departments of Metabolism, Endocrinology and Molecular Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
Cardiovasc Diabetol. 2014 Jan 10;13:10. doi: 10.1186/1475-2840-13-10.
The adipocyte-derived hormone leptin plays a key role in the regulation of appetite and body weight. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-related atherosclerosis and cardiovascular disease. In this study, we investigated the association of plasma leptin levels with vascular endothelial function in lean and overweight patients with type 2 diabetes.
One hundred seventy-one type 2 diabetic patients, of which 85 were overweight (body mass index (BMI) ≥ 25 kg/m2), were enrolled in this cross-sectional study. Plasma leptin concentrations were measured by enzyme-linked immunosorbent assay. Flow-mediated dilatation (FMD) of the brachial artery was measured to evaluate vascular endothelial function using ultrasound.
No significant difference in FMD was found between the lean and overweight groups (7.0 ± 3.8% and 6.5 ± 3.6%, respectively; p = 0.354). FMD was negatively correlated with age (r = -0.371, p < 0.001) and serum creatinine levels (r = -0.236, p = 0.030), but positively correlated with BMI (r = 0.330, p = 0.002) and plasma leptin levels (r = 0.290, p = 0.007) in the overweight group. FMD was not associated with any parameters in the lean group. Multiple regression analysis including possible atherosclerotic risk factors revealed that the plasma leptin level (β = 0.427, p = 0.013) was independently associated with FMD in the overweight group (R2 = 0.310, p = 0.025), but not the lean group.
Plasma leptin levels are associated with vascular endothelial function in overweight patients with type 2 diabetes.
脂肪细胞分泌的激素瘦素在食欲和体重调节中起关键作用。最近的研究表明，瘦素也参与肥胖相关动脉粥样硬化和心血管疾病的发病机制。在本研究中，我们调查了体重正常和超重的2型糖尿病患者血浆瘦素水平与血管内皮功能之间的关联。
171例2型糖尿病患者纳入本横断面研究，其中85例超重（体重指数（BMI）≥25kg/m²）。采用酶联免疫吸附测定法测量血浆瘦素浓度。使用超声测量肱动脉血流介导的舒张功能（FMD）以评估血管内皮功能。
体重正常组和超重组的FMD无显著差异（分别为7.0±3.8%和6.5±3.6%；p=0.354）。在超重组中，FMD与年龄（r=-0.371，p<0.001）和血清肌酐水平（r=-0.236，p=0.030）呈负相关，但与BMI（r=0.330，p=0.002）和血浆瘦素水平（r=0.290，p=0.007）呈正相关。在体重正常组中，FMD与任何参数均无关联。包括可能的动脉粥样硬化危险因素的多元回归分析显示，超重患者组中血浆瘦素水平（β=0.427，p=0.013）与FMD独立相关（R²=0.310，p=0.025），而体重正常组则不然。
超重的2型糖尿病患者血浆瘦素水平与血管内皮功能相关。
