RAB GTPases 和 RAB 相互作用蛋白及其在认知功能调控中的作用。
RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions.
机构信息
Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy; Vita-Salute San Raffaele University, via Olgettina 58, 20132 Milan, Italy.
Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy.
出版信息
Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:302-14. doi: 10.1016/j.neubiorev.2013.12.009. Epub 2014 Jan 9.
A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.
一种与 RAS 相关的小分子单体 G 蛋白家族，RAB GTPases，在囊泡形成、运输和融合的特定隔室方向控制中具有关键的生物学重要性。由于人类遗传观察以及随后的专门生化工作，人们在理解 RAB GTPases 及其效应蛋白在神经元发育和认知功能形成中的作用方面取得了重大进展。本文综述了这些初始元素，以拓宽目前对发育认知障碍的研究范围，并从 RAB GTPases 对神经元和星形胶质细胞中膜运输的控制角度来看待问题。
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