Amendola Beatriz E, Amendola Marco, Perez Naipy, Iglesias Alejandro, Wu Xiaodong
Innovative Cancer Institute, 6141 Sunset Drive, Suite 102, South Miami, FL 33143, USA.
Rep Pract Oncol Radiother. 2013 Aug 17;18(6):383-6. doi: 10.1016/j.rpor.2013.07.005.
AIM/BACKGROUND: To evaluate how the use of volumetric-modulated arc therapy (VMAT) with RapidArc(®) can improve treatment delivery efficiency based on the analysis of the beam-on times and monitor units (MU) needed to deliver therapy for multiple clinical applications in a large patient population.
A total of 898 treatment courses were delivered in 745 patients treated from October 2008 to March 2013 using RapidArc® treatment plans generated in Eclipse™ TPS. All patients were treated with curative or palliative intent using different techniques including conventional fractionation (83%) and radiosurgery or SBRT (17%), depending on the clinical indications. Treatment delivery was evaluated based on measured beam-on time and recorded MU values delivered on a Varian Trilogy™ linear accelerator.
For conventional fractionation treatments using RapidArc®, the delivery times ranged from 38 s to 4 min and 40 s (average 2 min and 6 s). For radiosurgical treatments the delivery times ranged from 1 min and 42 s to 9 min and 22 s (average 4 min and 4 s). The average number of MU per Gy was 301 for the entire group, with 285 for the conventional group and 317 for the radiosurgical group.
In this study with a large heterogeneous population, treatments using RapidArc® were delivered with substantially less beam-on time and fewer MUs than conventional fractionation. This was highly advantageous, increasing flexibility of the scheduling allowing treatment of radiosurgery patients during the regular daily work schedule. Additionally, reduction of leakage radiation dose was achieved.
目的/背景:通过分析为大量患者群体的多种临床应用提供治疗所需的照射时间和监测单位(MU),评估容积调强弧形治疗(VMAT)与RapidArc(®)技术的联合使用如何提高治疗交付效率。
2008年10月至2013年3月期间,对745例患者共进行了898个疗程的治疗,使用Eclipse™治疗计划系统生成的RapidArc(®)治疗计划。所有患者根据临床指征,采用包括常规分割(83%)和放射外科或立体定向体部放疗(SBRT,17%)在内的不同技术进行根治性或姑息性治疗。基于在Varian Trilogy™直线加速器上测量的照射时间和记录的MU值来评估治疗交付情况。
对于使用RapidArc(®)的常规分割治疗,照射时间范围为38秒至4分40秒(平均2分6秒)。对于放射外科治疗,照射时间范围为1分42秒至9分22秒(平均4分4秒)。整个组每Gy的平均MU数为301,常规组为285,放射外科组为317。
在这项包含大量异质性人群的研究中,与常规分割相比,使用RapidArc(®)进行的治疗照射时间明显更短,MU数更少。这具有很大优势,增加了日程安排的灵活性,使得放射外科患者能够在日常常规工作时间内接受治疗。此外,还实现了漏射线剂量的降低。