JAK-STAT信号传导与心肌葡萄糖代谢。
JAK-STAT signaling and myocardial glucose metabolism.
作者信息
Frias Miguel A, Montessuit Christophe
机构信息
Division of Endocrinology, Diabetology and Nutrition; University of Geneva School of Medicine; Geneva, Switzerland.
Division of Cardiology; Department of Medical Specialties; University of Geneva School of Medicine; Geneva, Switzerland.
出版信息
JAKSTAT. 2013 Oct 1;2(4):e26458. doi: 10.4161/jkst.26458. Epub 2013 Sep 27.
JAK-STAT signaling occurs in virtually every tissue of the body, and so does glucose metabolism. In this review, we summarize the regulation of glucose metabolism in the myocardium and ponder whether JAK-STAT signaling participates in this regulation. Despite a paucity of data directly pertaining to cardiac myocytes, we conclude that JAK-STAT signaling may contribute to the development of insulin resistance in the myocardium in response to various hormones and cytokines.
JAK-STAT信号传导几乎发生在身体的每个组织中，葡萄糖代谢也是如此。在本综述中，我们总结了心肌中葡萄糖代谢的调节，并思考JAK-STAT信号传导是否参与了这种调节。尽管直接与心肌细胞相关的数据很少，但我们得出结论，JAK-STAT信号传导可能在心肌中因各种激素和细胞因子而导致胰岛素抵抗的发展中起作用。
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