线纹香茶菜中的二萜类化合物。

Diterpenoids from Isodon sculponeatus.

作者信息

Jiang Hua-Yi, Wang Wei-Guang, Zhou Min, Wu Hai-Yan, Zhan Rui, Li Xiao-Nian, Du Xue, Li Yan, Pu Jian-Xin, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.

出版信息

Fitoterapia. 2014 Mar;93:142-9. doi: 10.1016/j.fitote.2013.12.025. Epub 2014 Jan 10.

DOI:10.1016/j.fitote.2013.12.025

PMID:24418655

Abstract

Phytochemical investigation of the aerial parts of Isodon sculponeatus afforded six new 7,20-epoxy-ent-kauranoids, sculponins U-Z (1-6), and 11 known diterpenoids (7-17). The structures of these new compounds were elucidated primarily by means of extensive spectroscopic analysis, and the absolute configuration of 1 was determined by single crystal X-ray diffraction. Compound 5 exhibited weak cytotoxic activity against HL-60, SMMC-7721, MCF-7, and SW-480 cell lines, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 13.8 μM.

摘要

对糙叶香茶菜地上部分进行的植物化学研究得到了6个新的7,20-环氧-对映-贝壳杉烷型二萜，即糙叶香茶菜素U-Z（1-6），以及11个已知的二萜类化合物（7-17）。这些新化合物的结构主要通过广泛的光谱分析得以阐明，化合物1的绝对构型通过单晶X射线衍射确定。化合物5对HL-60、SMMC-7721、MCF-7和SW-480细胞系表现出较弱的细胞毒活性，并且它还抑制脂多糖刺激的RAW264.7细胞中一氧化氮的产生，IC50值为13.8 μM。