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[白木香叶的进一步化学研究]

[Further chemical investigation of leaves of Aquilaria Sinensis].

作者信息

Xia Fang, Sun Jian, Jiang Yong, Tu Peng-Fei

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3299-303.

Abstract

To comprehensively utilize the rich resource of Aquilaria sinensis,the ethanol extract of the leaves of A. sinensis was further chemically investigated, which led to the isolation of 12 compounds. By means of 'H- , "C-NMR, and ESI-MS data, and through comparison with those reported in literatures,their structures were identified as iriflophenone 2-(O-a-L)-rhamnoside(1) ,4'-hydroxy-5 methoxyflavone-7-O-glucoxyloside (2) ,7,3',5'-tri-O-methyltricetin(3) ,7-O-beta-D-glucopyranoside of 5-O-methylapigenin(4) ,2-phenyl-ethyl-D-glucopyranoside( 5), salidroside, (6) , benzyl alcohol O-beta-D-glucopyranoside (7) , 2, 6-dimethoxy-4-hydroxyphenol-1-O-beta-D-glucopyranoside(8) ,vanilloloside(9) , ( + ) -syringaresinol( 10) ,beta-tocopherol( 11) and stigmast-5-ene-3beta,7alpha-diol( 12). Among them, compounds 2,3,5-9,11 and 12 were isolated from this genus for the first time. This research hopefully provides valuable data for the further utilization and development of the leaves of A. sinensis.

摘要

为了全面利用沉香丰富的资源,对沉香叶的乙醇提取物进行了进一步的化学研究,从中分离出12种化合物。通过¹H-、¹³C-NMR和ESI-MS数据,并与文献报道的数据进行比较,确定它们的结构分别为鸢尾黄酮2-(O-α-L)-鼠李糖苷(1)、4'-羟基-5-甲氧基黄酮-7-O-葡萄糖苷(2)、7,3',5'-三-O-甲基三刺芹素(3)、5-O-甲基芹菜素7-O-β-D-葡萄糖苷(4)、2-苯乙基-D-葡萄糖苷(5)、红景天苷(6)、苄醇O-β-D-葡萄糖苷(7)、2,6-二甲氧基-4-羟基苯酚-1-O-β-D-葡萄糖苷(8)、香草醇苷(9)、(+)-丁香树脂醇(10)、β-生育酚(11)和豆甾-5-烯-3β,7α-二醇(12)。其中,化合物2、3、5-9、11和12首次从该属植物中分离得到。该研究有望为沉香叶的进一步利用和开发提供有价值的数据。

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