Vasant Rupal A, Patel Namrata D, Karn Sanjay S, V R L Narasimhacharya Amaravadi
Laboratory for Animal Sciences, Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar, India.
J Pharmacopuncture. 2014 Jun;17(2):34-40. doi: 10.3831/KPI.2014.17.014.
The objective of the present study was to investigate the lipid and the antioxidant regulatory potential of a multigrain diet in laboratory animals with reference to lipid profiles, tissue lipid peroxidation and antioxidant status.
Two types of diets, with or without addition of cholesterol, were used in the study - a commercial diet and a formulated multigrain diet (with Sorghum vulgare, Avena sativa, Pennisetum typhoideum, Oryza sativa, Eleusine coracana and Zea mays grains). After a 10-week period of feeding the diets to albino rats the plasma, liver and fecal lipid profiles and the hepatic and renal antioxidant status of the animals that were fed the commercial and the formulated diets (with and without cholesterol addition) were assessed.
The commercial diet supplemented with cholesterol elevated the levels of plasma total lipids, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C), as well as the atherogenic index (AI). The high-density lipoprotein cholesterol (HDL-C) content and the antioxidant profiles (total ascorbic acid, superoxide dismutase, catalase, glutathione peroxidase reduced glutathione) declined along with increases in lipid peroxidation. The formulated diet (with and without addition of cholesterol) was found to be more efficient than the commercial diet in controlling plasma, hepatic and fecal lipid profiles, as well as hepatic and renal lipid peroxidation and antioxidant status, than of the hypercholesteremic animals.
The multigrain diet used in the present study is effective in countering the hyperlipidemia and oxidative stress caused by high cholesterol intake.
本研究的目的是参照血脂谱、组织脂质过氧化和抗氧化状态，调查多谷物饮食对实验动物脂质和抗氧化调节的潜力。
本研究使用了两种饮食，一种添加胆固醇，一种不添加胆固醇——一种商业饮食和一种配制的多谷物饮食（含有高粱、燕麦、黍、水稻、薏苡和玉米谷物）。在给白化大鼠喂食这两种饮食10周后，评估喂食商业饮食和配制饮食（添加和不添加胆固醇）的动物的血浆、肝脏和粪便脂质谱以及肝脏和肾脏的抗氧化状态。
添加胆固醇的商业饮食提高了血浆总脂质、总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）的水平，以及动脉粥样硬化指数（AI）。高密度脂蛋白胆固醇（HDL-C）含量和抗氧化指标（总抗坏血酸、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、还原型谷胱甘肽）随着脂质过氧化的增加而下降。发现配制饮食（添加和不添加胆固醇）在控制血浆、肝脏和粪便脂质谱以及肝脏和肾脏脂质过氧化和抗氧化状态方面比商业饮食更有效，优于高胆固醇血症动物。
本研究中使用的多谷物饮食可有效对抗高胆固醇摄入引起的高脂血症和氧化应激。
