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鼻窦肿瘤的管理:预后因素与结果:一家三级医院的10年经验

Management of sinonasal tumors: prognostic factors and outcomes: a 10 year experience at a tertiary care hospital.

作者信息

Kazi Maliha, Awan Sohail, Junaid Montasir, Qadeer Sadaf, Hassan Nabeel Humayun

机构信息

Head and Neck Surgery, Department of Oto-rhinolaryngology, Aga Khan University Hospital, Karachi, 75500 Pakistan ; Aga Khan University Hospital, Stadium Road, Karachi, 74800 Pakistan.

Head and Neck Surgery, Department of Oto-rhinolaryngology, Aga Khan University Hospital, Karachi, 75500 Pakistan.

出版信息

Indian J Otolaryngol Head Neck Surg. 2013 Jul;65(Suppl 1):155-9. doi: 10.1007/s12070-013-0650-x. Epub 2013 Apr 7.

Abstract

Sinonasal malignancies are said to be a highly heterogeneous group of cancers, accounting for less than 1 % of all cancers and less than 3 % of all upper aerodigestive tract tumors. Originating from any histologic components of the sinonasal cavity, the histopathology of these tumors is diverse. Accordingly, treatment options vary, surgery being the mainstay in most of them. Recurrence rates differs with each histological type of tumor, dependent on various factors. In this article, we have tried to identify the prevalent characteristics of sinonasal malignancies and to outline the prognostic factors affecting the outcome. It is a retrospective study design with a total number of 102 patients. Patients diagnosed with sinonasal malignancies were included and any patient previously operated outside our institute or having received prior radiation or chemotherapy were excluded. The patients were selected over a period of 10 years, from 2000 to 2010. Data was analyzed using SPSS 17. Majority of the sinonasal tumors were squamous cell carcinomas involving the maxillary sinus. Locoregional recurrence was found to be more frequent in patients with positive neck nodes on final histopathology. Sinonasal malignancies are mostly squamous cell in variety and recurrence of these rare entities is dependent on the histological variety and the presence of positive neck nodes.

摘要

鼻窦恶性肿瘤据说是一组高度异质性的癌症,占所有癌症的比例不到1%,占所有上消化道呼吸道肿瘤的比例不到3%。这些肿瘤起源于鼻窦腔的任何组织学成分,其组织病理学多种多样。因此,治疗方案各不相同,大多数情况下手术是主要治疗手段。复发率因肿瘤的每种组织学类型而异,取决于多种因素。在本文中,我们试图确定鼻窦恶性肿瘤的普遍特征,并概述影响预后的因素。这是一项回顾性研究设计,共有102例患者。纳入被诊断为鼻窦恶性肿瘤的患者,排除任何之前在我们研究所之外接受过手术或曾接受过放疗或化疗的患者。这些患者是在2000年至2010年的10年期间挑选出来的。使用SPSS 17进行数据分析。大多数鼻窦肿瘤是累及上颌窦的鳞状细胞癌。最终组织病理学显示颈部淋巴结阳性的患者局部区域复发更为常见。鼻窦恶性肿瘤大多为鳞状细胞类型,这些罕见实体的复发取决于组织学类型和颈部淋巴结阳性情况。

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