Richette Pascal, Molto Anna, Viguier Manuel, Dawidowicz Karen, Hayem Gilles, Nassif Aude, Wendling Daniel, Aubin François, Lioté Frédéric, Bachelez Hervé
From the Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Lariboisière, Pôle appareil locomoteur, Fédération de Rhumatologie; University Paris Diderot, Sorbonne Paris Cité, Paris, France; Universitat Autonoma de Barcelona, Departament de Medicina, Barcelona, Spain; AP-HP, Hôpital Saint-Louis, Service de Dermatologie, Immunité anti virale, Biothérapie et Vaccins; Institut Pasteur, Sorbonne Paris Cité, Université Paris Diderot; AP-HP, Hôpital Bichat, Service de Rhumatologie; Université Paris Diderot, Sorbonne Paris Cité; Institut Pasteur, Centre médical, Paris; Service de Rhumatologie, Service de Dermatologie, Université de Franche-Comté, Besançon-Inserm, UMR S606, Centre Viggo Petersen, Hôpital Lariboisière; AP-HP, Hôpital Saint-Louis, Service de Dermatologie, INSERM U781, Hôpital Necker Enfants-Malades, Sorbonne Paris Cité Université, Paris Diderot, Paris, France.
J Rheumatol. 2014 Mar;41(3):490-4. doi: 10.3899/jrheum.130977. Epub 2014 Jan 15.
To determine the prevalence and characterize the inflammatory musculoskeletal symptoms of hidradenitis suppurativa (HS), a chronic inflammatory disease of skin appendages.
Patients with HS referred to 3 dermatology university hospital centers were systematically screened for peripheral arthritis, dactylitis, inflammatory back pain, or enthesitis. After careful clinical examination, patients were further classified according to clinical and imaging criteria for spondyloarthritis (SpA) using the Amor, European Spondyloarthropathy Study Group (ESSG), and ASsessment in ankylosing spondylitis (ASAS).
We screened 640 patients with HS; 184 had musculoskeletal symptoms. In all, 43 (mean age 39.4 yrs, ± 8.3; 80% women) had arthritis, inflammatory back pain, or enthesitis and were investigated further. Signs of HS preceded the onset of articular symptoms in 39 patients (90%), at a mean interval of 3.6 years. A total of 18 (41%), 24 (55%), and 15 (34%) patients fulfilled the Amor, ESSG, and ASAS criteria, respectively, while synovitis, acne, pustolosis, hyperostosis, and osteitis (SAPHO) syndrome was established in 4 patients. The crude prevalence of SpA in all 640 patients with HS was 3.7% by the ESSG criteria.
SpA may occur in patients with HS, with the prevalence in this group exceeding that in the general population. The very short time between skin and joint symptom onset in some cases suggests common pathogenic mechanisms underlying HS and SpA.
确定化脓性汗腺炎（HS）这一皮肤附属器慢性炎症性疾病的炎性肌肉骨骼症状的患病率并对其进行特征描述。
对转诊至3家大学皮肤科医院中心的HS患者系统性筛查外周关节炎、指（趾）炎、炎性背痛或附着点炎。经过仔细的临床检查后，根据脊柱关节炎（SpA）的临床和影像学标准，使用Amor标准、欧洲脊柱关节病研究组（ESSG）标准和强直性脊柱炎评估（ASAS）标准对患者进行进一步分类。
我们筛查了640例HS患者；184例有肌肉骨骼症状。总共有43例（平均年龄39.4岁，±8.3；80%为女性）有关节炎、炎性背痛或附着点炎，并进行了进一步调查。39例（90%）患者的HS体征先于关节症状出现，平均间隔时间为3.6年。分别有18例（41%）、24例（55%）和15例（34%）患者符合Amor标准、ESSG标准和ASAS标准，同时4例患者确诊为滑膜炎、痤疮、脓疱病、骨肥厚和骨炎（SAPHO）综合征。根据ESSG标准，在所有640例HS患者中SpA的粗患病率为3.7%。
SpA可能发生在HS患者中，该组患病率高于一般人群。某些病例中皮肤和关节症状发作间隔时间极短，提示HS和SpA存在共同的致病机制。
