通过IgE抗体检测到的桦树花粉、蔬菜和水果之间的交叉反应性至少归因于三种不同的交叉反应结构。

Cross-reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross-reactive structures.

作者信息

Calkhoven P G, Aalbers M, Koshte V L, Pos O, Oei H D, Aalberse R C

出版信息

Allergy. 1987 Jul;42(5):382-90. doi: 10.1111/j.1398-9995.1987.tb02225.x.

DOI:10.1111/j.1398-9995.1987.tb02225.x

Abstract

Sera of patients suffering from birch pollinosis were studied in the radio-allergo-sorbent test (RAST) for the presence of IgE antibodies to various allergens of vegetable origin. The sera selected were positive in the RAST for both birch pollen and fruits. IgE antibodies directed against at least three different cross-reacting determinants in birch pollen were detected. In addition to periodate-susceptible cross-reacting determinants, which are found on a number of glycoproteins, two non-related periodate-resistant determinants were found in birch pollen, with molecular weights of 20 and 18 kD, respectively. The 20-kD component appears to be responsible for the co-occurrence of the binding of IgE to allergens of fresh fruits, whereas the 18-kD component appears to cause the cross-reactivity among grass pollen, potato and fruits.

摘要

对患有桦树花粉症患者的血清进行了放射变应原吸附试验（RAST），以检测针对各种植物源性过敏原的IgE抗体。所选血清在针对桦树花粉和水果的RAST中呈阳性。检测到针对桦树花粉中至少三种不同交叉反应决定簇的IgE抗体。除了在许多糖蛋白上发现的对高碘酸盐敏感的交叉反应决定簇外，在桦树花粉中还发现了两种不相关的对高碘酸盐耐受的决定簇，分子量分别为20kD和18kD。20-kD成分似乎是导致IgE与新鲜水果过敏原结合同时出现的原因，而18-kD成分似乎导致了草花粉、土豆和水果之间的交叉反应。