Bauer L, Ebner C, Hirschwehr R, Wüthrich B, Pichler C, Fritsch R, Scheiner O, Kraft D
Institute of General and Experimental Pathology, AKH, University of Vienna, Austria.
Clin Exp Allergy. 1996 Oct;26(10):1161-70. doi: 10.1111/j.1365-2222.1996.tb00503.x.
Allergy to celery is often associated with sensitization to birch and/or mugwort pollen.
In a multi-centre study, sera from 23 patients suffering from type 1 allergy to celery and 15 patients with positive celery RAST but no clinical sensitization were compared. To examine whether cross-reactivity between celery and mugwort pollen includes cross-sensitization to birch pollen allergens, we determined cross-reacting structures in birch pollen, mugwort pollen and celery by means of immunoblotting. Inhibition studies were performed by preincubation of sera with extracts of birch pollen, mugwort pollen, and celery.
We identified three groups of proteins--homologues of Bet v 1 and birch profilin (Bet v 2) as well as a group of proteins with a molecular range of 46 to 60 kD--displaying IgE-cross-reactivity, which were shared by birch pollen and celery. Two of these groups of allergens (profilin and the 46 to 60 kD proteins) were also present in mugwort pollen. In this paper we demonstrate that most cross-reacting allergens present in mugwort pollen and celery can also be detected in birch pollen extract.
Therefore we propose, from a serological point of view, to extend the mugwort-celery syndrome to the birch-mugwort-celery syndrome.
芹菜过敏常与桦树和/或艾蒿花粉致敏相关。
在一项多中心研究中，对23例1型芹菜过敏患者和15例芹菜RAST阳性但无临床致敏患者的血清进行了比较。为了研究芹菜与艾蒿花粉之间的交叉反应是否包括对桦树花粉过敏原的交叉致敏，我们通过免疫印迹法测定了桦树花粉、艾蒿花粉和芹菜中的交叉反应结构。通过将血清与桦树花粉、艾蒿花粉和芹菜提取物预孵育进行抑制研究。
我们鉴定出三组蛋白质——Bet v 1和桦树肌动蛋白结合蛋白（Bet v 2）的同源物以及一组分子量范围为46至60 kD的蛋白质——呈现IgE交叉反应性，这些蛋白质在桦树花粉和芹菜中都有。其中两组过敏原（肌动蛋白结合蛋白和46至60 kD的蛋白质）也存在于艾蒿花粉中。在本文中我们证明，在艾蒿花粉和芹菜中存在的大多数交叉反应性过敏原也可以在桦树花粉提取物中检测到。
因此，从血清学角度出发，我们建议将艾蒿-芹菜综合征扩展为桦树-艾蒿-芹菜综合征。
