Aarons Cary B
Division of Colon and Rectal Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
Clin Colon Rectal Surg. 2013 Jun;26(2):122-7. doi: 10.1055/s-0033-1348051.
Crohn disease remains a challenging clinical entity, both medically and surgically. It frequently presents in early adulthood and imposes a lifetime exposure to chronic inflammation that can affect the entire gastrointestinal tract. Although the mainstay of therapy is treatment with immunomodulating drugs, ∼70 to 90% of patients with Crohn disease will ultimately require surgery. Furthermore, there are high rates of symptomatic recurrences that may also require surgical intervention over time. There is no definitive cure for Crohn disease and surgery is reserved for failed medical therapy or the complications of the disease, namely, obstruction, septic complications (abscess, perforation), and fistulas. However, the robust inflammatory environment during these periods is not always conducive to a minimally invasive surgical approach. Despite the inherent technical challenges, the literature has increasingly shown that laparoscopy for Crohn disease, in the appropriate setting, is feasible and safe. In fact, it offers many advantages, which are particularly beneficial to this subset of patients, such as fewer wound complications, a shortened hospital course, less tissue trauma and subsequent adhesion formation, and earlier resumption of oral intake and bowel function.
克罗恩病在医学和外科治疗方面仍然是一个具有挑战性的临床实体。它通常在成年早期出现,使患者终生暴露于可影响整个胃肠道的慢性炎症中。尽管治疗的主要方法是使用免疫调节药物,但约70%至90%的克罗恩病患者最终仍需要手术治疗。此外,症状复发率很高,随着时间的推移可能也需要手术干预。克罗恩病无法彻底治愈,手术仅用于药物治疗失败或出现疾病并发症的情况,即梗阻、感染性并发症(脓肿、穿孔)和瘘管。然而,这些时期强烈的炎症环境并不总是有利于微创外科手术方法。尽管存在固有的技术挑战,但文献越来越多地表明,在适当的情况下,针对克罗恩病的腹腔镜手术是可行且安全的。事实上,它具有许多优势,对这类患者尤其有益,例如伤口并发症更少、住院时间缩短、组织创伤和随后的粘连形成更少,以及更早恢复经口进食和肠道功能。