Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Curr Opin Neurobiol. 2014 Jun;26(100):79-87. doi: 10.1016/j.conb.2013.12.012. Epub 2014 Jan 15.
The origins of cortical interneurons in rodents have been localized to the embryonic subcortical telencephalon where distinct neuroepithelial precursors generate defined interneuron subsets. A swathe of research activity aimed at identifying molecular determinants of subtype identity has uncovered a number of transcription factors that function at different stages of interneuron development. Pathways that lead to the acquisition of mature interneuron traits are therefore beginning to emerge. As genetic programs are influenced by external factors the search continues not only into genetic determinants but also extrinsic influences and the interplay between the two in cell fate specification.
在啮齿动物中，皮质中间神经元的起源被定位到胚胎皮质下端脑中，在那里，不同的神经上皮前体产生特定的中间神经元亚群。大量旨在确定亚型身份的分子决定因素的研究活动发现了许多转录因子，它们在中间神经元发育的不同阶段发挥作用。因此，导致获得成熟中间神经元特征的途径开始显现出来。由于遗传程序受到外部因素的影响，因此不仅在遗传决定因素方面，而且在外在影响及其在细胞命运特化中的相互作用方面的研究仍在继续。
