用于组织工程的聚（3-羟基丁酸酯-co-3-羟基己酸酯）基支架
Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-based scaffolds for tissue engineering.
作者信息
Chang H M, Wang Z H, Luo H N, Xu M, Ren X Y, Zheng G X, Wu B J, Zhang X H, Lu X Y, Chen F, Jing X H, Wang L
机构信息
Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Xi'an Medical University, Xi'an, China.
Department of Otolaryngology-Head and Neck Surgery, The Second Hospital, Xi'an Jiaotong University, Xi'an, China.
出版信息
Braz J Med Biol Res. 2014 Jul;47(7):533-9. doi: 10.1590/1414-431x20143930. Epub 2014 May 30.
Abstract
Development and selection of an ideal scaffold is of importance for tissue engineering. Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a biocompatible bioresorbable copolymer that belongs to the polyhydroxyalkanoate family. Because of its good biocompatibility, PHBHHx has been widely used as a cell scaffold for tissue engineering. This review focuses on the utilization of PHBHHx-based scaffolds in tissue engineering. Advances in the preparation, modification, and application of PHBHHx scaffolds are discussed.
摘要
开发和选择理想的支架材料对于组织工程至关重要。聚（3-羟基丁酸酯-co-3-羟基己酸酯）（PHBHHx）是一种生物相容性可生物降解的共聚物，属于聚羟基脂肪酸酯家族。由于其良好的生物相容性，PHBHHx已被广泛用作组织工程的细胞支架。本文综述聚焦于基于PHBHHx的支架材料在组织工程中的应用。讨论了PHBHHx支架材料在制备、改性及应用方面的进展。
相似文献
1
Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-based scaffolds for tissue engineering.
Braz J Med Biol Res. 2014 Jul;47(7):533-9. doi: 10.1590/1414-431x20143930. Epub 2014 May 30.
2
The properties of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) and its applications in tissue engineering.
Curr Stem Cell Res Ther. 2014 May;9(3):215-22. doi: 10.2174/1574888x09666140213160853.
3
The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model.
Biomaterials. 2013 Sep;34(28):6683-94. doi: 10.1016/j.biomaterials.2013.05.041. Epub 2013 Jun 13.
4
Biocompatibility studies and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/polycaprolactone blends.
J Biomed Mater Res B Appl Biomater. 2013 Jul;101(5):752-61. doi: 10.1002/jbm.b.32878. Epub 2013 Jan 29.
5
Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)/collagen hybrid scaffolds for tissue engineering applications.
Tissue Eng Part C Methods. 2013 Aug;19(8):577-85. doi: 10.1089/ten.TEC.2012.0457. Epub 2013 Feb 14.
6
Additive manufacturing of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] scaffolds for engineered bone development.
J Tissue Eng Regen Med. 2017 Jan;11(1):175-186. doi: 10.1002/term.1897. Epub 2014 May 30.
7
Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds coated with PhaP-RGD fusion protein promotes the proliferation and chondrogenic differentiation of human umbilical cord mesenchymal stem cells in vitro.
J Biomed Mater Res A. 2015 Mar;103(3):1169-75. doi: 10.1002/jbm.a.35265. Epub 2014 Jul 18.
8
Mesoporous bioactive glass doped-poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) composite scaffolds with 3-dimensionally hierarchical pore networks for bone regeneration.
Colloids Surf B Biointerfaces. 2014 Apr 1;116:72-80. doi: 10.1016/j.colsurfb.2013.12.052. Epub 2013 Dec 30.
9
Siliceous mesostructured cellular foams/poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) composite biomaterials for bone regeneration.
Int J Nanomedicine. 2014 Oct 20;9:4795-807. doi: 10.2147/IJN.S52421. eCollection 2014.
10
Studies on bone marrow stromal cells affinity of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate).
Biomaterials. 2004 Mar-Apr;25(7-8):1365-73. doi: 10.1016/j.biomaterials.2003.08.018.
引用本文的文献
1
Metabolic Engineering Strategies for Enhanced Polyhydroxyalkanoate (PHA) Production in .
Polymers (Basel). 2025 Jul 31;17(15):2104. doi: 10.3390/polym17152104.
2
Enhancing the Potential of PHAs in Tissue Engineering Applications: A Review of Chemical Modification Methods.
Materials (Basel). 2024 Nov 27;17(23):5829. doi: 10.3390/ma17235829.
3
Processing and Properties of Polyhydroxyalkanoate/ZnO Nanocomposites: A Review of Their Potential as Sustainable Packaging Materials.
Polymers (Basel). 2024 Oct 30;16(21):3061. doi: 10.3390/polym16213061.
4
Materials designed to degrade: structure, properties, processing, and performance relationships in polyhydroxyalkanoate biopolymers.
Polym Chem. 2024 Oct 15;16(3):235-265. doi: 10.1039/d4py00623b. eCollection 2025 Jan 14.
5
Haloarchaeal poly[(3-hydroxybutyrate)--(3-hydroxyvalerate)] composite films reinforced with graphene nanoplatelets as a biomaterial for skin tissue engineering.
RSC Adv. 2024 Aug 5;14(34):24398-24412. doi: 10.1039/d4ra00713a.
6
Nucleating and reinforcing effects of nanobiochar on poly(3-hydroxybutyrate--3-hydroxhexanoate) bionanocomposites.
RSC Adv. 2024 Jul 12;14(30):21971-21981. doi: 10.1039/d3ra08721b. eCollection 2024 Jul 5.
7
Natural Polyhydroxyalkanoates-An Overview of Bacterial Production Methods.
Molecules. 2024 May 13;29(10):2293. doi: 10.3390/molecules29102293.
8
A Review on Electroactive Polymer-Metal Composites: Development and Applications for Tissue Regeneration.
J Funct Biomater. 2023 Oct 17;14(10):523. doi: 10.3390/jfb14100523.
9
Biomaterials-mediated CRISPR/Cas9 delivery: recent challenges and opportunities in gene therapy.
Front Chem. 2023 Sep 28;11:1259435. doi: 10.3389/fchem.2023.1259435. eCollection 2023.
10
Three-Dimensional Scaffolds for Bone Tissue Engineering.
Bioengineering (Basel). 2023 Jun 25;10(7):759. doi: 10.3390/bioengineering10070759.
本文引用的文献
1
The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model.
Biomaterials. 2013 Sep;34(28):6683-94. doi: 10.1016/j.biomaterials.2013.05.041. Epub 2013 Jun 13.
2
Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates.
Biomaterials. 2013 May;34(15):3737-46. doi: 10.1016/j.biomaterials.2013.01.088. Epub 2013 Feb 22.
3
Hyaluronic acid based scaffolds for tissue engineering--a review.
Carbohydr Polym. 2013 Feb 15;92(2):1262-79. doi: 10.1016/j.carbpol.2012.10.028. Epub 2012 Oct 17.
4
Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)/collagen hybrid scaffolds for tissue engineering applications.
Tissue Eng Part C Methods. 2013 Aug;19(8):577-85. doi: 10.1089/ten.TEC.2012.0457. Epub 2013 Feb 14.
5
Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin.
Acta Biomater. 2013 Feb;9(2):5063-9. doi: 10.1016/j.actbio.2012.09.034. Epub 2012 Oct 2.
6
Studies of in situ-forming hydrogels by blending PLA-PEG-PLA copolymer with silk fibroin solution.
J Biomed Mater Res A. 2012 Aug;100(8):1983-9. doi: 10.1002/jbm.a.33307. Epub 2012 May 5.
7
A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles.
Biomaterials. 2012 Feb;33(5):1583-8. doi: 10.1016/j.biomaterials.2011.10.072. Epub 2011 Nov 21.
8
The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARγ signaling.
Biomaterials. 2012 Jan;33(2):485-93. doi: 10.1016/j.biomaterials.2011.09.089. Epub 2011 Oct 19.
9
PHBV microspheres as neural tissue engineering scaffold support neuronal cell growth and axon-dendrite polarization.
Acta Biomater. 2012 Feb;8(2):540-8. doi: 10.1016/j.actbio.2011.09.026. Epub 2011 Sep 28.
10
Effect of initial cell seeding density on 3D-engineered silk fibroin scaffolds for articular cartilage tissue engineering.
Biomaterials. 2011 Dec;32(34):8927-37. doi: 10.1016/j.biomaterials.2011.08.027. Epub 2011 Sep 8.
Zotero 插件