Taylor F G, Jones C D, Bourne J
Department of Veterinary Medicine, University of Bristol, Langford, England.
Appl Environ Microbiol. 1987 Aug;53(8):1721-9. doi: 10.1128/aem.53.8.1721-1729.1987.
This paper reports an experiment designed to demonstrate that the calf lung can be sensitized to a specific respirable challenge following parenteral immunization with a nonliving antigen (human serum albumin). The possibility that immune-mediated injury could subsequently interfere with nonspecific mucosal defenses was also investigated by infecting calves with Pasteurella haemolytica after the antigen challenge and assessing pulmonary clearance of the organism. The results indicated that specific aerosol challenge produces reversible signs of respiratory hypersensitivity and that persistence of incidental infection in the upper respiratory tract is potentiated. Since the calves were sensitized by an immunization regime which imitated conventional vaccination, this study highlights the potential dangers of inactivated parenteral respiratory vaccines.
本文报道了一项实验，该实验旨在证明，在用非活性抗原（人血清白蛋白）进行肠胃外免疫后，小牛肺可对特定的可吸入激发物产生致敏作用。在抗原激发后，通过用溶血巴斯德氏菌感染小牛并评估该微生物的肺部清除情况，还研究了免疫介导的损伤随后可能干扰非特异性黏膜防御的可能性。结果表明，特定的气溶胶激发会产生呼吸道超敏反应的可逆迹象，并且上呼吸道中偶然感染的持续时间会延长。由于小牛是通过模仿传统疫苗接种的免疫方案致敏的，因此本研究突出了非活性肠胃外呼吸道疫苗的潜在危险。
