Xiao Yan, Yuan Ming, Zhang Jun, Yan Jinliang, Lang Meidong
Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Curr Top Med Chem. 2014;14(6):781-818. doi: 10.2174/1568026614666140118222820.
Recent advances in synthesis of functional poly-ε-caprolactone (PCL) and its self-assembly behavior, as well as application in drug delivery have been reviewed. Three strategies including end group functionalization, postpolymerization modification and new monomer preparation have been summarized to show possibilities for PCL derivatives. Complex architectures like cyclic and multi-arm PCL have been emphasized. Both chemical composition and topology have coordinately affected the property of PCL-based materials on the molecular level. A large variety of PCLs with sophisticated topology like block, graft, cyclic, and star have displayed versatile morphologies in solutions. These selfassembly aggregates have been applied as nano-scaled drug carries either to physically encapsulate or covalently conjugate drugs for controlled release. In particular, PCL with pendant groups has been extensively studied to illustrate the noncovalent interaction with drugs and the influence on the release profile. In general, functional PCL has shown great potential in construct of complicated supramolecular structures, and thus as ideal drug carriers for sustainable and targeted delivery.
本文综述了功能性聚己内酯（PCL）的合成、自组装行为及其在药物递送中的应用的最新进展。总结了包括端基功能化、后聚合改性和新型单体制备在内的三种策略，以展示PCL衍生物的可能性。强调了环状和多臂PCL等复杂结构。化学成分和拓扑结构在分子水平上协同影响了基于PCL的材料的性能。各种具有复杂拓扑结构（如嵌段、接枝、环状和星形）的PCL在溶液中表现出多样的形态。这些自组装聚集体已被用作纳米级药物载体，用于物理包封或共价结合药物以实现控释。特别是，带有侧基的PCL已被广泛研究，以阐明其与药物的非共价相互作用以及对释放曲线的影响。总体而言，功能性PCL在构建复杂的超分子结构方面显示出巨大潜力，因此是可持续和靶向递送的理想药物载体。
