Bianchi Eleonora, Ruggeri Marco, Vigani Barbara, Aguzzi Carola, Rossi Silvia, Sandri Giuseppina
Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Department of Pharmacy and Pharmaceutical Technology, University of Granada, Cartuja Campus, Granada 18071, Spain.
Int J Pharm X. 2024 Dec 17;9:100313. doi: 10.1016/j.ijpx.2024.100313. eCollection 2025 Jun.
Thermoplastic polymers provide a versatile platform to mimic various aspects of physiological extracellular matrix properties such as chemical composition, stiffness, and topography for use in cell and tissue engineering applications. In this review, we provide a brief overview of the most promising thermoplastic polymers, and in particular the thermoplastic polyesters, such as poly(lactic acid), poly(glycolic acid), and polycaprolactone, and the thermoplastic elastomers, such as polyurethanes, polyhydroxyalkanoates, and poly(butyl cyanoacrylate). A particular focus has been made on the synthesis processes, the processability and the biocompatibility. We also discuss how these materials can be applied in tissue engineering, mimicking tissues' structure and function, and stimulate mesenchymal stem cells differentiation and mechanotransduction.
热塑性聚合物提供了一个多功能平台，可用于模仿生理细胞外基质特性的各个方面，如化学成分、硬度和拓扑结构，以用于细胞和组织工程应用。在本综述中，我们简要概述了最有前景的热塑性聚合物，特别是热塑性聚酯，如聚乳酸、聚乙醇酸和聚己内酯，以及热塑性弹性体，如聚氨酯、聚羟基脂肪酸酯和聚氰基丙烯酸丁酯。特别关注了合成过程、加工性能和生物相容性。我们还讨论了这些材料如何应用于组织工程，模仿组织的结构和功能，并刺激间充质干细胞的分化和机械转导。
