Hassan Natalia, Oyarzun-Ampuero Felipe, Lara Pablo, Guerrero Simón, Cabuil Valérie, Abou-Hassan Ali, Kogan Marcelo J
UPMC Université Paris 6: Pierre et Marie Curie (UPMC), Laboratoire de Physico-Chimie des Electrolytes Colloïdes et Sciences Analytiques (PECSA), 4 place Jussieu, 75005, Paris-France.
Curr Top Med Chem. 2014 Mar;14(5):676-89. doi: 10.2174/1568026614666140118213915.
In this article we review the flow chemistry methodologies for the controlled synthesis of different kind of nano and microparticles for biomedical applications. Injection mechanism has emerged as new alternative for the synthesis of nanoparticles due to this strategy allows achieving superior levels of control of self-assemblies, leading to higher-ordered structures and rapid chemical reactions. Self-assembly events are strongly dependent on factors such as the local concentration of reagents, the mixing rates, and the shear forces, which can be finely tuned, as an example, in a microfluidic device. Injection methods have also proved to be optimal to elaborate microsystems comprising polymer solutions. Concretely, extrusion based methods can provide controlled fluid transport, rapid chemical reactions, and cost-saving advantages over conventional reactors. We provide an update of synthesis of nano and microparticles such as core/shell, Janus, nanocrystals, liposomes, and biopolymeric microgels through flow chemistry, its potential bioapplications and future challenges in this field are discussed.
在本文中，我们综述了用于生物医学应用的不同类型纳米和微粒的可控合成的流动化学方法。注射机制已成为合成纳米颗粒的新方法，因为这种策略能够实现对自组装的更高级别控制，从而形成更高阶的结构并实现快速化学反应。自组装过程强烈依赖于诸如试剂的局部浓度、混合速率和剪切力等因素，例如，在微流控装置中可以对这些因素进行精细调节。注射方法也已被证明是制备包含聚合物溶液的微系统的最佳方法。具体而言，基于挤出的方法相比于传统反应器能够提供可控的流体传输、快速化学反应以及成本节约的优势。我们介绍了通过流动化学合成纳米和微粒（如核壳结构、Janus颗粒、纳米晶体、脂质体和生物聚合物微凝胶）的最新情况，并讨论了其潜在的生物应用以及该领域未来的挑战。
