Awasthi Shally, Vikram Kumar
Department of Pediatrics and Translational Medicine Unit, King George's Medical University, Lucknow, 226003, India,
Indian J Pediatr. 2014 Jul;81(7):644-9. doi: 10.1007/s12098-013-1310-6. Epub 2014 Jan 21.
To assess the association between serum 25 hydroxy vitamin D levels and asthma and its control in Indian children.
This was a prospective case-control study conducted in tertiary care hospital. Cases of asthma and healthy age-matched controls were included, aged 1-15 y, who had not received any vitamin D supplementation in the last year and had no other co-morbidity, after obtaining written informed parental consent. 25 hydroxy vitamin D insufficiency was taken below level of ≤ 30 ng/mL.
Fifty asthmatics and 25 age-matched controls were recruited from August 2011-July 2012. 25 hydroxy vitamin D insufficiency was associated with occurrence of asthma (OR = 13.5; 95 % CI = 4.25-42.85: p = 0.000). With decreasing level of asthma control there was increasing strength of association with 25 hydroxy vitamin D insufficiency [χ (2) for trend = 24.96 (p = 0.000)].
25 hydroxy vitamin D insufficiency is associated with bronchial asthma as well as its level of control.
评估印度儿童血清25羟维生素D水平与哮喘及其控制之间的关联。
这是一项在三级护理医院进行的前瞻性病例对照研究。纳入年龄在1至15岁之间的哮喘患儿及年龄匹配的健康对照，这些患儿在过去一年未接受任何维生素D补充，且无其他合并症，研究已获得家长书面知情同意。25羟维生素D不足定义为水平≤30 ng/mL。
2011年8月至2012年7月招募了50名哮喘患儿和25名年龄匹配的对照。25羟维生素D不足与哮喘的发生相关（OR = 13.5；95% CI = 4.25 - 42.85：p = 0.000）。随着哮喘控制水平的降低，与25羟维生素D不足的关联强度增加[趋势χ(2) = 24.96（p = 0.000）]。
25羟维生素D不足与支气管哮喘及其控制水平相关。
