Javed Fawad, Ahmed Hameeda Bashir, Mehmood Abid, Bain Crawford, Romanos Georgios E
Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Lab., College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia,
Clin Oral Investig. 2014 Nov;18(8):1963-8. doi: 10.1007/s00784-014-1185-6. Epub 2014 Jan 22.
The aim of the present short-term longitudinal randomized case-control study was to assess the effect of nonsurgical periodontal therapy (NSPT) (with and without oral doxycycline delivery) on glycemic status and clinical periodontal parameters in patients with prediabetes.
Sixty-six patients with prediabetes and periodontal disease were included. Characteristics of the study cohort (age, gender, socioeconomic status [SES] education status, duration of prediabetes, and type of treatment adopted for prediabetes management) were recorded. Patients were randomly divided into two groups (33 patients/group). In group 1, scaling and root planing (SRP) was performed, and in group-2, patients underwent SRP and oral doxycycline (100 mg) administration once daily for 15 days. In each group, the following parameters were investigated at baseline and after 3 months: (a) fasting blood glucose level (FBGL), (b) hemoglobin A1c (HbA1c), and (c) periodontal parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and clinical attachment loss [AL]). Statistical analysis was performed using Student's t test.
There was no significant difference in age, gender, SES, education status, and duration and treatment of prediabetes among individuals in groups 1 and 2. Three months post-NSPT, FBGL and HbA1c were significantly reduced among patients in group 1 (P < 0.05) and group 2 (P < 0.05) compared to baseline. Three months post-NSPT, PI (P < 0.05), BOP (P < 0.05), and PD (P < 0.05) were significantly reduced among patients in group 1 (P < 0.05) and group 2 (P < 0.05) compared to baseline. There was no difference in clinical AL between the groups after 3 months of NSPT.
NSPT (with and without oral doxycycline delivery) reduces hyperglycemia and periodontal inflammation in patients with prediabetes.
本短期纵向随机病例对照研究的目的是评估非手术牙周治疗（NSPT）（使用和不使用口服强力霉素）对糖尿病前期患者血糖状态和临床牙周参数的影响。
纳入66例患有糖尿病前期和牙周疾病的患者。记录研究队列的特征（年龄、性别、社会经济地位[SES]、教育程度、糖尿病前期持续时间以及糖尿病前期管理所采用的治疗类型）。患者被随机分为两组（每组33例患者）。第1组进行龈上洁治和根面平整（SRP），第2组患者接受SRP并每天口服一次强力霉素（100mg），持续15天。在每组中，于基线和3个月后调查以下参数：（a）空腹血糖水平（FBGL），（b）糖化血红蛋白（HbA1c），以及（c）牙周参数（菌斑指数[PI]、探诊出血[BOP]、探诊深度[PD]和临床附着丧失[AL]）。使用学生t检验进行统计分析。
第1组和第2组个体在年龄、性别、SES、教育程度以及糖尿病前期的持续时间和治疗方面无显著差异。NSPT后3个月，与基线相比，第1组（P < 0.05）和第2组（P < 0.05）患者的FBGL和HbA1c显著降低。NSPT后3个月，与基线相比，第1组（P < 0.05）和第2组（P < 0.05）患者的PI（P < 0.05）、BOP（P < 0.05）和PD（P < 0.05）显著降低。NSPT 3个月后，两组之间的临床AL无差异。
NSPT（使用和不使用口服强力霉素）可降低糖尿病前期患者的高血糖和牙周炎症。
