Marconcini Simone, Giammarinaro Enrica, Cosola Saverio, Oldoini Giacomo, Genovesi Annamaria, Covani Ugo
Department of Stomatology, Tuscan Stomatologic Institute, Foundation for Dental Clinic, Research and Continuing Education, 55041 Camaiore, Italy.
Department of Dentistry, Unicamillus International Medical University, 00100 Rome, Italy.
Antioxidants (Basel). 2021 Jun 30;10(7):1056. doi: 10.3390/antiox10071056.
Periodontal infection may contribute to poor glycemic control and systemic inflammation in diabetic patients. The aim of the present study is to evaluate the efficacy of non-surgical periodontal treatment in diabetic patients by measuring oxidative stress outcomes.
Sixty diabetic patients with periodontitis were enrolled, treated with scaling and full-mouth disinfection, and randomly prescribed chlorhexidine mouthwash, antioxidant mouthwash, or ozone therapy. Reactive oxygen metabolites (ROMs), periodontal parameters, and glycated hemoglobin were measured at baseline and then at 1, 3, and 6 months after.
At baseline, all patients presented with pathologic levels of plasmatic ROM (388 ± 21.36 U CARR), higher than the normal population. Probing depth, plaque index, and bleeding on probing values showed significant clinical improvements after treatment, accompanied by significant reductions of plasma ROM levels ( < 0.05). At the 6-month evaluation, the mean ROM relapsed to 332 ± 31.76 U CARR. Glycated hemoglobin decreased significantly (∆ = -0.52 units) after treatment. Both the test groups showed longer-lasting improvements of periodontal parameters.
In diabetic patients, periodontal treatment was effective at reducing plasma ROM, which is an indicator of systemic oxidative stress and inflammation. The treatment of periodontal infection might facilitate glycemic control and decrease systemic inflammation.
牙周感染可能导致糖尿病患者血糖控制不佳和全身炎症。本研究旨在通过测量氧化应激指标来评估非手术牙周治疗对糖尿病患者的疗效。
纳入60例患有牙周炎的糖尿病患者，进行龈上洁治和全口消毒治疗，并随机给予洗必泰漱口水、抗氧化漱口水或臭氧治疗。在基线时以及治疗后1、3和6个月测量活性氧代谢产物（ROMs）、牙周参数和糖化血红蛋白。
基线时，所有患者的血浆ROM水平均处于病理水平（388±21.36 U CARR），高于正常人群。治疗后，探诊深度、菌斑指数和探诊出血值均有显著临床改善，同时血浆ROM水平显著降低（<0.05）。在6个月评估时，平均ROM水平回升至332±31.76 U CARR。治疗后糖化血红蛋白显著降低（∆=-0.52个单位）。两个试验组的牙周参数改善持续时间更长。
在糖尿病患者中，牙周治疗可有效降低血浆ROM水平，血浆ROM是全身氧化应激和炎症的指标。牙周感染的治疗可能有助于血糖控制并减轻全身炎症。
