Koltovaya N A
Genetika. 2013 Jul;49(7):797-813. doi: 10.7868/s0016675813050093.
Cyclin-dependent kinases (CDKs) are a family of enzymes essential for the progression of the cells through the cell cycle in eukaryotes. Moreover, genetic stability-maintaining processes, such as checkpoint control and DNA repair, require the phosphorylation of a wide variety of target substrates by CDK. In budding yeast Saccharomyces cerevisiae, the key role in the cell cycle progression is played by CDK1/CDC28 kinase. This enzyme is the most thoroughly investigated. In this review the involvement of CDC28 kinase in regulation of the cell cycle is discussed in the light of newly obtained data.
细胞周期蛋白依赖性激酶(CDKs)是一类酶,对于真核生物细胞通过细胞周期的进程至关重要。此外,诸如检查点控制和DNA修复等维持遗传稳定性的过程,需要CDK对多种靶底物进行磷酸化。在芽殖酵母酿酒酵母中,CDK1/CDC28激酶在细胞周期进程中起关键作用。这种酶是研究最深入的。在本综述中,根据新获得的数据讨论了CDC28激酶在细胞周期调控中的作用。