癸酸诺龙给药后促性腺激素对大鼠卵巢的调节作用：一项体视学研究。
Modulatory effect of gonadotropins on rats' ovaries after nandrolone decanoate administration: a stereological study.
作者信息
Bordbar Hossein, Mesbah Fakhroddin, Talaei Tahereh, Dehghani Farzaneh, Mirkhani Hossein
机构信息
Stereology and Histomorphometry Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; ; Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
出版信息
Iran J Med Sci. 2014 Jan;39(1):44-50.
BACKGROUND
Nandrolone decanoate (ND) is an anabolic androgenic steroid (AAS) which influences the ovarian structure and function. We assessed the effects of ND on the ovarian volume, number of primordial follicles, and level of hormones and also evaluated the modulatory effects of gonadotropins on the histopathological changes imposed by the administration of ND.
METHODS
Six groups of Sprague-Dawley adult female rats (n=30) were used. The experimental rats were injected intraperitoneally with 3 and 10 mg/kg ND with or without human menopausal gonadotropin (hMG), 10 IU weekly for one month. The vehicle and control rats were administered olive oil and saline, respectively, for the same period of time. The ovarian volume and number of primordial follicles were estimated by stereological methods.
RESULTS
The results showed a decrease in the ovarian volume, number of primordial follicles, and level of gonadotropins in the ND-treated animals compared with the vehicle groups. In the rats treated with 3 mg/kg of ND with hMG, an increase in the ovarian volume and number of primordial follicles was shown as compared to the rats treated with the same dose of ND without hMG.
CONCLUSION
ND exerted detrimental effects on the dimensions of the ovary, number of follicles, and level of sex hormones. However, hMG, prevented the harmful effects of ND (at least in a low dose) on the ovarian follicles.
背景
癸酸诺龙（ND）是一种合成代谢雄激素类固醇（AAS），会影响卵巢结构和功能。我们评估了ND对卵巢体积、原始卵泡数量和激素水平的影响，还评估了促性腺激素对ND给药所致组织病理学变化的调节作用。
方法
使用六组成年Sprague-Dawley雌性大鼠（n = 30）。实验大鼠腹腔注射3和10 mg/kg ND，同时或不同时注射人绝经期促性腺激素（hMG），每周10 IU，共注射一个月。赋形剂组和对照组大鼠在相同时间段内分别给予橄榄油和生理盐水。通过体视学方法估计卵巢体积和原始卵泡数量。
结果
结果显示，与赋形剂组相比，接受ND治疗的动物卵巢体积、原始卵泡数量和促性腺激素水平均下降。在接受3 mg/kg ND和hMG治疗的大鼠中，与接受相同剂量ND但未接受hMG治疗的大鼠相比，卵巢体积和原始卵泡数量有所增加。
结论
ND对卵巢大小、卵泡数量和性激素水平产生有害影响。然而，hMG可预防ND（至少在低剂量时）对卵巢卵泡的有害影响。
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