May Christian Albrecht
Department of Anatomy, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstra β e 74, 01307 Dresden, Germany.
ScientificWorldJournal. 2013 Dec 25;2013:378206. doi: 10.1155/2013/378206. eCollection 2013.
Several aspects of chronologic and biologic aging in the human choroid are reviewed from the literature. They often reveal methodological problems for age-dependent changes of the following parameters: choroidal thickness, choroidal pigmentation, choroidal vasculature and blood flow, and choroidal innervation. On reinterpreting some data of studies concerning Bruch's membrane, changes observed at different age points seem more likely to be nonlinear. Concluding from the data presented so far, chronologic aging should not be used as a factor for physiological changes in the human choroid. Longitudinal study designs are necessary to further establish the impact of age. Meanwhile, a more biologic oriented model of aging processes in the choroid should be established, including specified conditions (e.g., light exposure and refractory state). This would help to define more individual strategies for prevention and early stages of a certain defined disease.
本文从文献中回顾了人类脉络膜在时间和生物学老化方面的几个方面。它们常常揭示了以下参数随年龄变化的方法学问题：脉络膜厚度、脉络膜色素沉着、脉络膜血管系统和血流以及脉络膜神经支配。在重新解释一些关于布鲁赫膜的研究数据时，在不同年龄点观察到的变化似乎更有可能是非线性的。根据目前所呈现的数据得出结论，不应将时间老化用作人类脉络膜生理变化的一个因素。需要纵向研究设计来进一步确定年龄的影响。同时，应建立一个更以生物学为导向的脉络膜老化过程模型，包括特定条件（如光照和不应期状态）。这将有助于为某种特定疾病的预防和早期阶段确定更个性化的策略。
