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静磁场对糖尿病大鼠伤口愈合的治疗作用

Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats.

作者信息

Zhao Jing, Li Yong-Guo, Deng Kai-Qin, Yun Peng, Gong Ting

机构信息

Central Laboratory, Medical School of Yangtze University, Hubei 434003, China.

Department of Endocrinology, Central Hospital of Jingzhou City, Hubei 434001, China.

出版信息

J Diabetes Res. 2017;2017:6305370. doi: 10.1155/2017/6305370. Epub 2017 Mar 26.

DOI:10.1155/2017/6305370
PMID:28459073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5385228/
Abstract

. To investigate the effects of static magnetic field (SMF) on cutaneous wound healing of Streptozotocin- (STZ-) induced diabetic rats. . 20 STZ-induced diabetic rats were randomly divided into two groups (10 in each group): diabetic rats with SMF exposure group which were exposed to SMF by gluing one magnetic disk of 230 mT intensity and diabetic rats with sham SMF exposure group (sham group). 10 normal Wistar rats were used as the control group. One open circular wound with 2 cm diameter in the dorsum was generated on both normal and diabetic rats and then covered with sterile gauzes. Wound healing was evaluated by wound area reduction rate, mean time to wound closure, and wound tensile strength. . The wound area reduction rate in diabetic rats in comparison with the control group was significantly decreased ( < 0.01). Compared with sham magnet group, diabetic rats under 230 mT SMF exposure demonstrated significantly accelerated wound area reduction rate on postoperative days 7, 14, and 21 and decreased gross time to wound closure ( < 0.05), as well as dramatically higher wound tissue strength ( < 0.05) on 21st day. . 230 mT SMF promoted the healing of skin wound in diabetic rats and may provide a non-invasive therapeutic tool for impaired wound healing of diabetic patients.

摘要

研究静磁场（SMF）对链脲佐菌素（STZ）诱导的糖尿病大鼠皮肤伤口愈合的影响。将20只STZ诱导的糖尿病大鼠随机分为两组（每组10只）：SMF暴露糖尿病大鼠组，通过粘贴一块强度为230 mT的磁盘使其暴露于SMF；假SMF暴露糖尿病大鼠组（假手术组）。10只正常Wistar大鼠作为对照组。在正常大鼠和糖尿病大鼠的背部均制作一个直径为2 cm的开放性圆形伤口，然后用无菌纱布覆盖。通过伤口面积缩小率、伤口闭合平均时间和伤口抗张强度来评估伤口愈合情况。与对照组相比，糖尿病大鼠的伤口面积缩小率显著降低（P<0.01）。与假磁体组相比，暴露于230 mT SMF的糖尿病大鼠在术后第7天、14天和21天伤口面积缩小率显著加快，伤口闭合总时间缩短（P<0.05），并且在第21天伤口组织强度显著更高（P<0.05）。230 mT SMF促进了糖尿病大鼠皮肤伤口的愈合，可能为糖尿病患者伤口愈合受损提供一种非侵入性治疗工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffb/5385228/d6aba0a55072/JDR2017-6305370.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffb/5385228/0a2126f42bb2/JDR2017-6305370.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffb/5385228/05a668ce128b/JDR2017-6305370.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffb/5385228/d6aba0a55072/JDR2017-6305370.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffb/5385228/0a2126f42bb2/JDR2017-6305370.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffb/5385228/05a668ce128b/JDR2017-6305370.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffb/5385228/d6aba0a55072/JDR2017-6305370.003.jpg

相似文献

[1]
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[2]
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[3]
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[4]
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[10]
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引用本文的文献

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APL Bioeng. 2024-3-13

[2]
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[3]
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[4]
Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications.

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[5]
Notoginsenoside R1 Facilitated Wound Healing in High-Fat Diet/Streptozotocin-Induced Diabetic Rats.

Oxid Med Cell Longev. 2022

[6]
Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials.

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[7]
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[8]
Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation.

J Diabetes Res. 2019-11-30

[9]
Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?

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本文引用的文献

[1]
Magnetic nanocomposite scaffolds combined with static magnetic field in the stimulation of osteoblastic differentiation and bone formation.

Biomaterials. 2016-4

[2]
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review.

Diabetes Metab Res Rev. 2016-1

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[8]
Effects of 180 mT static magnetic fields on diabetic wound healing in rats.

Bioelectromagnetics. 2010-12

[9]
Pulsed electromagnetic fields accelerate wound healing in the skin of diabetic rats.

Bioelectromagnetics. 2010-5

[10]
The effect of magnetic fields on wound healing: experimental study and review of the literature.

Eplasty. 2008-7-25

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