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DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.

作者信息

Porteous D J, Thomson P A, Millar J K, Evans K L, Hennah W, Soares D C, McCarthy S, McCombie W R, Clapcote S J, Korth C, Brandon N J, Sawa A, Kamiya A, Roder J C, Lawrie S M, McIntosh A M, St Clair D, Blackwood D H

机构信息

Centre for Genomic and Experimental Medicine, MRC/University of Edinburgh Institute of Genetics & Molecular Medicine, Western General Hospital, Edinburgh, UK.

Institute for Molecular Medicine Finland FIMM, Biomedicum Helsinki 2U, Helsinki, Finland.

出版信息

Mol Psychiatry. 2014 Feb;19(2):141-3. doi: 10.1038/mp.2013.160.

DOI:10.1038/mp.2013.160
PMID:24457522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4238281/
Abstract
摘要

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本文引用的文献

1
DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking.DISC1 复合物与 TRAK1 和 Miro1 结合，调节顺行轴突线粒体的运输。
Hum Mol Genet. 2014 Feb 15;23(4):906-19. doi: 10.1093/hmg/ddt485. Epub 2013 Oct 2.
2
Questions about DISC1 as a genetic risk factor for schizophrenia.关于DISC1作为精神分裂症遗传风险因素的问题。
Mol Psychiatry. 2013 Oct;18(10):1050-2. doi: 10.1038/mp.2012.182.
3
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.基于全基因组 SNP 估算的五种精神障碍的遗传关系。
Nat Genet. 2013 Sep;45(9):984-94. doi: 10.1038/ng.2711. Epub 2013 Aug 11.
4
708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.在 1542 名受试者中鉴定出 708 个常见和 2010 个罕见的 DISC1 基因座变异：分析与精神障碍和认知特征的关联。
Mol Psychiatry. 2014 Jun;19(6):668-75. doi: 10.1038/mp.2013.68. Epub 2013 Jun 4.
5
DISC1 genetics, biology and psychiatric illness.精神分裂症1基因、生物学与精神疾病
Front Biol (Beijing). 2013 Feb 1;8(1):1-31. doi: 10.1007/s11515-012-1254-7.
6
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.五种主要精神疾病具有共同影响的风险基因座的鉴定：全基因组分析。
Lancet. 2013 Apr 20;381(9875):1371-1379. doi: 10.1016/S0140-6736(12)62129-1. Epub 2013 Feb 28.
7
DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders.DECIPHER：一个基于网络的、用于发育障碍中罕见变异临床解读的社区资源。
Hum Mol Genet. 2012 Oct 15;21(R1):R37-44. doi: 10.1093/hmg/dds362. Epub 2012 Sep 8.
8
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.与精神分裂症和情感障碍相关的 t(1;11)易位导致异常嵌合 DISC1 转录本的产生，这些转录本编码结构改变的、有害的线粒体蛋白。
Hum Mol Genet. 2012 Aug 1;21(15):3374-86. doi: 10.1093/hmg/dds169. Epub 2012 Apr 30.
9
Deep resequencing and association analysis of schizophrenia candidate genes.精神分裂症候选基因的深度重测序与关联分析
Mol Psychiatry. 2013 Feb;18(2):138-40. doi: 10.1038/mp.2012.28. Epub 2012 Apr 3.
10
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.DISC1 变体 37W 和 607F 破坏了其在 ATF4 介导的转录中的核靶向和调节作用。
Hum Mol Genet. 2012 Jun 15;21(12):2779-92. doi: 10.1093/hmg/dds106. Epub 2012 Mar 15.