DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.
作者信息
Porteous D J, Thomson P A, Millar J K, Evans K L, Hennah W, Soares D C, McCarthy S, McCombie W R, Clapcote S J, Korth C, Brandon N J, Sawa A, Kamiya A, Roder J C, Lawrie S M, McIntosh A M, St Clair D, Blackwood D H
机构信息
Centre for Genomic and Experimental Medicine, MRC/University of Edinburgh Institute of Genetics & Molecular Medicine, Western General Hospital, Edinburgh, UK.
Institute for Molecular Medicine Finland FIMM, Biomedicum Helsinki 2U, Helsinki, Finland.
出版信息
Mol Psychiatry. 2014 Feb;19(2):141-3. doi: 10.1038/mp.2013.160.
Abstract
摘要
相似文献
1
DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.
Mol Psychiatry. 2014 Feb;19(2):141-3. doi: 10.1038/mp.2013.160.
2
A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.
J Biol Chem. 2017 Apr 21;292(16):6468-6477. doi: 10.1074/jbc.M116.773903. Epub 2017 Mar 1.
3
Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.
Biol Psychiatry. 2009 Jun 15;65(12):1055-62. doi: 10.1016/j.biopsych.2009.01.014. Epub 2009 Feb 28.
4
Association on DISC1 SNPs with schizophrenia risk: A meta-analysis.
Psychiatry Res. 2018 Dec;270:306-309. doi: 10.1016/j.psychres.2018.09.056. Epub 2018 Sep 23.
5
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14501-6. doi: 10.1073/pnas.0704774104. Epub 2007 Aug 3.
6
Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness.
Schizophr Bull. 2006 Jul;32(3):409-16. doi: 10.1093/schbul/sbj079. Epub 2006 May 12.
7
Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings.
Schizophr Bull. 2007 Jan;33(1):11-5. doi: 10.1093/schbul/sbl063. Epub 2006 Nov 30.
8
DISC1 in schizophrenia: genetic mouse models and human genomic imaging.
Schizophr Bull. 2011 Jan;37(1):14-20. doi: 10.1093/schbul/sbq135. Epub 2010 Dec 13.
9
Disrupted-in-schizophrenia-1 (DISC1): a key susceptibility factor for major mental illnesses.
Ann N Y Acad Sci. 2006 Nov;1086:126-33. doi: 10.1196/annals.1377.018.
10
Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations.
Psychiatr Genet. 2010 Dec;20(6):298-303. doi: 10.1097/YPG.0b013e32833aa5c4.
引用本文的文献
1
Effects of psychosis-associated genetic markers on brain volumetry: a systematic review of replicated findings and an independent validation.
Psychol Med. 2022 Sep 28;52(16):1-16. doi: 10.1017/S0033291722002896.
2
The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment.
J Psychiatry Neurosci. 2022 Mar 31;47(2):E134-E147. doi: 10.1503/jpn.210145. Print 2022 Mar-Apr.
3
Recent Reports on Redox Stress-Induced Mitochondrial DNA Variations, Neuroglial Interactions, and NMDA Receptor System in Pathophysiology of Schizophrenia.
Mol Neurobiol. 2022 Apr;59(4):2472-2496. doi: 10.1007/s12035-021-02703-4. Epub 2022 Jan 27.
4
Mutations in DISC1 alter IPR and voltage-gated Ca channel functioning, implications for major mental illness.
Neuronal Signal. 2021 Dec 7;5(4):NS20180122. doi: 10.1042/NS20180122. eCollection 2021 Dec.
5
Mitochondrial Miro GTPases coordinate mitochondrial and peroxisomal dynamics.
Small GTPases. 2021 Sep-Nov;12(5-6):372-398. doi: 10.1080/21541248.2020.1843957. Epub 2020 Nov 12.
6
Lack of Helios During Neural Development Induces Adult Schizophrenia-Like Behaviors Associated With Aberrant Levels of the TRIF-Recruiter Protein WDFY1.
Front Cell Neurosci. 2020 May 14;14:93. doi: 10.3389/fncel.2020.00093. eCollection 2020.
7
Disorder Mediated Oligomerization of Proteins Revealed by Coarse-Grained Molecular Dynamics Simulations.
J Phys Chem B. 2019 Nov 14;123(45):9567-9575. doi: 10.1021/acs.jpcb.9b07467. Epub 2019 Oct 30.
8
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Mol Psychiatry. 2019 Nov;24(11):1641-1654. doi: 10.1038/s41380-019-0505-2. Epub 2019 Sep 3.
9
Disrupted-in-schizophrenia 1 functional polymorphisms and D /D receptor availability: A [ C]-(+)-PHNO imaging study.
Genes Brain Behav. 2019 Nov;18(8):e12596. doi: 10.1111/gbb.12596. Epub 2019 Jul 5.
10
Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia.
Transl Psychiatry. 2019 May 31;9(1):156. doi: 10.1038/s41398-019-0486-6.
本文引用的文献
1
DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking.
Hum Mol Genet. 2014 Feb 15;23(4):906-19. doi: 10.1093/hmg/ddt485. Epub 2013 Oct 2.
2
Questions about DISC1 as a genetic risk factor for schizophrenia.
Mol Psychiatry. 2013 Oct;18(10):1050-2. doi: 10.1038/mp.2012.182.
3
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Nat Genet. 2013 Sep;45(9):984-94. doi: 10.1038/ng.2711. Epub 2013 Aug 11.
4
708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.
Mol Psychiatry. 2014 Jun;19(6):668-75. doi: 10.1038/mp.2013.68. Epub 2013 Jun 4.
5
DISC1 genetics, biology and psychiatric illness.
Front Biol (Beijing). 2013 Feb 1;8(1):1-31. doi: 10.1007/s11515-012-1254-7.
6
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Lancet. 2013 Apr 20;381(9875):1371-1379. doi: 10.1016/S0140-6736(12)62129-1. Epub 2013 Feb 28.
7
DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders.
Hum Mol Genet. 2012 Oct 15;21(R1):R37-44. doi: 10.1093/hmg/dds362. Epub 2012 Sep 8.
8
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
Hum Mol Genet. 2012 Aug 1;21(15):3374-86. doi: 10.1093/hmg/dds169. Epub 2012 Apr 30.
9
Deep resequencing and association analysis of schizophrenia candidate genes.
Mol Psychiatry. 2013 Feb;18(2):138-40. doi: 10.1038/mp.2012.28. Epub 2012 Apr 3.
10
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.
Hum Mol Genet. 2012 Jun 15;21(12):2779-92. doi: 10.1093/hmg/dds106. Epub 2012 Mar 15.
Zotero 插件