From the Jinshikai Medical Foundation (O. Nishi, Y. Nishi, K. Nishi), Nishi Eye Hospital, Osaka, Japan; Calhoun Vision Institute (Chang), Pasadena, California, USA.
From the Jinshikai Medical Foundation (O. Nishi, Y. Nishi, K. Nishi), Nishi Eye Hospital, Osaka, Japan; Calhoun Vision Institute (Chang), Pasadena, California, USA.
J Cataract Refract Surg. 2014 Feb;40(2):295-305. doi: 10.1016/j.jcrs.2013.06.028.
To evaluate whether a new capsular bag-refilling procedure provides some accommodation in monkey eyes and to assess the difference in accommodation with different volumes of capsular bag refilling.
Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.
Experimental study.
A central 3.0 to 4.0 mm continuous curvilinear capsulorhexis was created, after which phacoemulsification was performed in the usual manner. A new accommodating-membrane intraocular lens (IOL) for sealing the capsular opening was implanted in the capsular bag. Silicone polymers were injected beneath the IOL into the capsular bag through the delivery hole. In 3 study groups, each with 6 monkey eyes, the lens capsule was refilled with 0.080 mL of silicone polymers, corresponding to a 65% bag volume; 0.100 mL, corresponding to an 80% bag volume; or 0.125 mL, corresponding to a 100% bag volume. To calculate the accommodation amplitudes achieved, automated refractometry was performed before and 1 hour after topical pilocarpine 4.0% application preoperatively and 4 weeks postoperatively.
The refilling technique was successful without polymer leakage in all monkeys. Four weeks after surgery, the mean accommodation amplitudes were 2.56 diopters (D) ± 0.74 (SD), 2.42 ± 1.00 D, and 2.71 ± 0.63 D, respectively, in the 3 study groups.
The technique provided some accommodation in young monkey eyes. Leakage of the injectable silicone polymers and anterior capsule opacification in the visual axis were avoided. The results suggest that the capsular bag-refilling procedure warrants further study for possible clinical application.
All authors have a proprietary interest in the accommodating membrane IOL mentioned in the article.
评估新的囊袋内填充程序是否能为猴子的眼睛提供一定的调节能力，并评估不同囊袋填充体积的调节能力差异。
日本大阪西眼科医院金日开医疗基金会。
实验研究。
创建一个中央 3.0 到 4.0 毫米的连续曲线囊膜环形撕囊，然后以通常的方式进行超声乳化。将一种新的用于密封囊口的可调节膜人工晶状体（IOL）植入囊袋内。通过输送孔将硅酮聚合物注入 IOL 下方的囊袋内。在 3 个研究组（每组 6 只猴子）中，分别向晶状体囊内注入 0.080 毫升硅酮聚合物，相当于囊袋体积的 65%；0.100 毫升，相当于 80%；或 0.125 毫升，相当于 100%。为了计算达到的调节幅度，在术前和术后 4 周，在局部滴用 4.0%毛果芸香碱前，通过自动折射计进行测量。
在所有猴子中，该填充技术均成功，无聚合物渗漏。术后 4 周，3 个研究组的平均调节幅度分别为 2.56 屈光度（D）±0.74（SD）、2.42±1.00 D 和 2.71±0.63 D。
该技术为年轻猴子的眼睛提供了一定的调节能力。避免了可注射硅酮聚合物的渗漏和视轴前方囊膜混浊。结果表明，囊袋内填充程序值得进一步研究，以可能应用于临床。
所有作者均对文章中提到的可调节膜 IOL 拥有所有权权益。
