Frea B, Annoscia S, Stanta G, Lozzi C, Carmignani G
Department of Clinical Urology, University of Trieste, Italy.
Urol Res. 1987;15(5):311-4. doi: 10.1007/BF00258203.
In elderly males hormonal changes occur, that are believed to cause benign prostatic hyperplasia (BPH). These are decreased testosterone production, an increased testosterone SHBG and a slightly increased estradiol production. Liver cirrhosis in males causes similar endocrine changes. We carried out a post mortem study evaluating the prostates of 51 men who died with liver cirrhosis compared with a similar group without any hepatic disease. The occurrence of BPH in cirrhotic subjects was diminished and delayed compared to total population. Furthermore in cirrhotic men BPH is more common as early nodular hyperplasia (early stage) or stromal hyperplasia (suggesting estrogenic prevalence), while in the general population stromal and epithelial hyperplasia (androgenic stimulation), were almost equally present.
老年男性会出现一些激素变化，这些变化被认为会导致良性前列腺增生（BPH）。这些变化包括睾酮分泌减少、睾酮与性激素结合球蛋白（SHBG）增加以及雌二醇分泌略有增加。男性肝硬化会导致类似的内分泌变化。我们进行了一项尸检研究，评估了51例死于肝硬化的男性的前列腺，并与一组无肝脏疾病的类似人群进行了比较。与总体人群相比，肝硬化患者中BPH的发生率降低且出现时间延迟。此外，在肝硬化男性中，BPH更常见于早期结节性增生（早期）或间质增生（提示雌激素占优势），而在普通人群中，间质和上皮增生（雄激素刺激）几乎同样常见。
