Thomas S, Drew R, Ersser R, Hjelm M, Stephens A
Department of Clinical Biochemistry, Hospital for Sick Children, London, UK.
Acta Haematol. 1987;78(2-3):144-8. doi: 10.1159/000205865.
Haemoglobin (Hb) A and Hb F has been determined in neonates of Afro-Caribbean and North European origin with gestational ages varying from 32 to 42 weeks. There was no difference in the distribution of Hb A/F ratios between the two groups. Only weak correlations could be established between the Hb A/F ratio and the estimated gestational age or birth weight. This would indicate that there is a considerable interindividual variation in the timing of the switching of haemoglobin synthesis from Hb F to Hb A and erythrocyte production from liver to bone marrow and of oxygen affinity of fetal blood. Thus, intra-uterine adjustments of the oxygen release capacity of haemoglobin would have to rest on biochemical mechanisms during the third trimester.
已对胎龄为32至42周的非洲加勒比裔和北欧裔新生儿的血红蛋白（Hb）A和Hb F进行了测定。两组之间Hb A/F比值的分布没有差异。Hb A/F比值与估计的胎龄或出生体重之间仅能建立微弱的相关性。这表明，从血红蛋白F合成转换为血红蛋白A、红细胞生成从肝脏转换至骨髓以及胎儿血液氧亲和力的转换时间存在相当大的个体间差异。因此，孕期第三个月血红蛋白氧释放能力的宫内调节将不得不依赖生化机制。
