Guo Ru-Ning, Lin Jin-Yan, Li Lin-Hui, Ke Chang-Wen, He Jian-Feng, Zhong Hao-Jie, Zhou Hui-Qiong, Peng Zhi-Qiang, Yang Fen, Liang Wen-Jia
Public Health Emergency management office, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China.
Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China.
PLoS One. 2014 Jan 23;9(1):e85596. doi: 10.1371/journal.pone.0085596. eCollection 2014.
Frequent outbreaks of dengue are considered to be associated with an increased risk for endemicity of the disease. The occurrence of a large number of indigenous dengue cases in consecutive years indicates the possibility of a changing dengue epidemic pattern in Guangdong, China.
To have a clear understanding of the current dengue epidemic, a retrospective study of epidemiological profile, serological response, and virological features of dengue infections from 2005-2011 was conducted. Case data were collected from the National Notifiable Infectious Diseases Reporting Network. Serum samples were collected and prepared for serological verification and etiological confirmation. Incidence, temporal and spatial distribution, and the clinical manifestation of dengue infections were analyzed. Pearson's Chi-Square test was used to compare incidences between different age groups. A seroprevalence survey was implemented in local healthy inhabitants to obtain the overall positive rate for the specific immunoglobulin (Ig) G antibody against dengue virus (DENV).
The overall annual incidence rate was 1.87/100000. A significant difference was found in age-specific incidence (Pearson's Chi-Square value 498.008, P<0.001). Children under 5 years of age had the lowest incidence of 0.28/100000. The vast majority of cases presented with a mild manifestation typical to dengue fever. The overall seroprevalence of dengue IgG antibody in local populations was 2.43% (range 0.28%-5.42%). DENV-1 was the predominant serotype in circulation through the years, while all 4 serotypes were identified in indigenous patients from different outbreak localities since 2009.
A gradual change in the epidemic pattern of dengue infection has been observed in recent years in Guangdong. With the endemic nature of dengue infections, the transition from a monotypic to a multitypic circulation of dengue virus in the last several years will have an important bearing on the prevention and control of dengue in the province and in the neighboring districts.
登革热的频繁爆发被认为与该病地方流行风险增加相关。连续多年出现大量本土登革热病例表明中国广东登革热流行模式可能正在发生变化。
为清楚了解当前登革热疫情，对2005 - 2011年登革热感染的流行病学特征、血清学反应及病毒学特征进行了回顾性研究。病例数据从国家法定传染病报告网络收集。采集血清样本用于血清学验证和病原学确认。分析登革热感染的发病率、时间和空间分布以及临床表现。采用Pearson卡方检验比较不同年龄组的发病率。在当地健康居民中开展血清流行率调查以获取针对登革病毒（DENV）的特异性免疫球蛋白（Ig）G抗体的总体阳性率。
年总发病率为1.87/10万。各年龄组发病率存在显著差异（Pearson卡方值498.008，P<0.001）。5岁以下儿童发病率最低，为0.28/10万。绝大多数病例表现为典型的登革热轻症。当地人群中登革热IgG抗体的总体血清流行率为2.43%（范围0.28% - 5.42%）。多年来DENV - 1是流行的主要血清型，而自2009年以来在不同爆发地区的本土患者中均鉴定出了所有4种血清型。
近年来在广东观察到登革热感染流行模式逐渐发生变化。鉴于登革热感染的地方性特点，过去几年登革病毒从单一血清型流行向多血清型流行的转变将对该省及周边地区的登革热防控产生重要影响。
