Furness J B, Costa M, Rökaeus A, McDonald T J, Brooks B
Centre for Neuroscience, Flinders University, Bedford Park, S.A. Australia.
Cell Tissue Res. 1987 Dec;250(3):607-15. doi: 10.1007/BF00218954.
Galanin immunoreactivity was observed in nerve cell bodies and nerve fibres, but not in enteroendocrine cells, in the small intestine of the guinea-pig. Nerve terminals were found in the myenteric plexus, in the circular muscle, in submucous ganglia, around submucous arterioles, and in the mucosa. Lesion studies showed that all terminals were intrinsic to the intestine; those in myenteric ganglia arose from cell bodies in more orally placed ganglia. Myenteric nerve cells were also the source of terminals in the circular muscle. Galanin (GAL) was located in a population of submucous nerve cell bodies that also showed immunoreactivity for vasoactive intestinal peptide (VIP) and in a separate population that was immunoreactive for neuropeptide Y (NPY). Processes of the GAL/VIP neurons supplied submucous arterioles and the mucosal epithelium. Processes of GAL/NPY neurons ran to the mucosa. It is concluded that galanin immunoreactivity occurs in several functionally distinct classes of enteric neurons, amongst which are neurons controlling (i) motility, (ii) intestinal blood flow, and (iii) mucosal water and electrolyte transport.
在豚鼠小肠中，在神经细胞体和神经纤维中观察到甘丙肽免疫反应性，但在肠内分泌细胞中未观察到。在肌间神经丛、环行肌、黏膜下神经节、黏膜下小动脉周围和黏膜中发现了神经末梢。损伤研究表明，所有末梢均为肠道固有；肌间神经节中的末梢起源于更靠近口腔位置的神经节中的细胞体。肌间神经细胞也是环行肌中神经末梢的来源。甘丙肽（GAL）存在于一群黏膜下神经细胞体中，这些细胞体对血管活性肠肽（VIP）也有免疫反应，并且存在于另一群对神经肽Y（NPY）有免疫反应的细胞中。GAL/VIP神经元的突起供应黏膜下小动脉和黏膜上皮。GAL/NPY神经元的突起延伸至黏膜。得出的结论是，甘丙肽免疫反应性存在于几类功能不同的肠神经元中，其中包括控制（i）运动、（ii）肠血流量以及（iii）黏膜水和电解质转运的神经元。
