与左氧氟沙星治疗相关的皮肤白细胞破碎性血管炎
Cutaneous leukocytoclastic vasculitis associated with levofloxacin therapy.
作者信息
Blyth Dana M, Markelz Elizabeth, Okulicz Jason F
机构信息
Department of Internal Medicine and.
Infectious Disease Service, San Antonio Military Medical Center, San Antonio, TX, USA.
出版信息
Infect Dis Rep. 2012 Jan 30;4(1):e11. doi: 10.4081/idr.2012.e11. eCollection 2012 Jan 2.
Abstract
Many cases of cutaneous vasculitis are drug-induced with histology revealing leukocytoclastic vasculitis (LCV). We present a case of levofloxacin-associated LCV successfully treated with prednisone and cessation of the offending drug. Although case reports describe a link between LCV and older fluoroquinolones, such as ciprofloxacin and ofloxacin, recent reports have implicated the newer fluoroquinolone levofloxacin. Recognition of fluoroquinolone-induced cutaneous vasculitis is important as continuation or re-exposure of the offending agent may have life-threatening consequences.
摘要
许多皮肤血管炎病例是药物诱发的，组织学检查显示为白细胞破碎性血管炎（LCV）。我们报告1例左氧氟沙星相关的LCV，通过泼尼松治疗及停用致病药物后成功治愈。尽管病例报告描述了LCV与较老的氟喹诺酮类药物（如环丙沙星和氧氟沙星）之间的联系，但最近的报告表明较新的氟喹诺酮类药物左氧氟沙星也与之有关。认识到氟喹诺酮诱发的皮肤血管炎很重要，因为继续使用或再次接触致病药物可能会产生危及生命的后果。
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