Okamura Ikue, Nakamura Yukitsugu, Katsurada Yuka, Sato Ken, Ikeda Takashi, Kimura Fumihiko
Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, Japan.
Intern Med. 2016;55(20):3047-3051. doi: 10.2169/internalmedicine.55.7170. Epub 2016 Oct 15.
Purpura fulminans (PF) is a life-threatening syndrome comprising progressive hemorrhagic necrosis due to disseminated intravascular coagulation and dermal vascular thrombosis that leads to purpura and tissue necrosis. Various therapies have been used to arrest the progression of this disease, however, there is no established treatment because of the variety of underlying causes. We herein present an adult case of PF associated with leukocytoclastic vasculitis triggered by antibiotic (levofloxacin) intake. As a result of our rapid and accurate identification of the underlying cause, corticosteroid therapy successfully repressed the inflammatory process. As far as we know, this is the first report of levofloxacin-associated PF.
暴发性紫癜（PF）是一种危及生命的综合征，由弥散性血管内凝血和皮肤血管血栓形成导致进行性出血性坏死，进而引起紫癜和组织坏死。已采用多种疗法来阻止该疾病的进展，然而，由于潜在病因的多样性，尚无既定的治疗方法。我们在此报告一例成人暴发性紫癜病例，该病例与因服用抗生素（左氧氟沙星）引发的白细胞破碎性血管炎相关。由于我们迅速准确地查明了潜在病因，皮质类固醇疗法成功抑制了炎症过程。据我们所知，这是首例关于左氧氟沙星相关性暴发性紫癜的报告。
