Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Protein Cell. 2014 Jan;5(1):21-35. doi: 10.1007/s13238-013-0002-3. Epub 2014 Jan 29.
It has been well established that most of the age-related diseases such as insulin resistance, type 2 diabetes, hypertension, cardiovascular disease, osteoporosis, and atherosclerosis are all closely related to metabolic dysfunction. On the other hand, interventions on metabolism such as calorie restriction or genetic manipulations of key metabolic signaling pathways such as the insulin and mTOR signaling pathways slow down the aging process and improve healthy aging. These findings raise an important question as to whether improving energy homeostasis by targeting certain metabolic signaling pathways in specific tissues could be an effective anti-aging strategy. With a more comprehensive understanding of the tissue-specific roles of distinct metabolic signaling pathways controlling energy homeostasis and the cross-talks between these pathways during aging may lead to the development of more effective therapeutic interventions not only for metabolic dysfunction but also for aging.
众所周知，大多数与年龄相关的疾病，如胰岛素抵抗、2 型糖尿病、高血压、心血管疾病、骨质疏松症和动脉粥样硬化，都与代谢功能障碍密切相关。另一方面，代谢干预，如热量限制或关键代谢信号通路（如胰岛素和 mTOR 信号通路）的遗传操作，可减缓衰老过程并改善健康衰老。这些发现提出了一个重要问题，即通过针对特定组织中的某些代谢信号通路来改善能量平衡，是否可以成为一种有效的抗衰老策略。更全面地了解控制能量平衡的不同代谢信号通路在特定组织中的作用，以及这些通路在衰老过程中的相互作用，可能会导致不仅针对代谢功能障碍，而且针对衰老的更有效的治疗干预措施的发展。
