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和基因的遗传多态性及其对呼伦贝尔羊生长性状的影响。

Genetic Polymorphisms of and Genes and Their Effects on Growth Traits in Hulun Buir Sheep.

机构信息

Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China.

University of Chinese Academy of Sciences, Beijing 100049, China.

出版信息

Genes (Basel). 2022 Apr 9;13(4):666. doi: 10.3390/genes13040666.

DOI:10.3390/genes13040666
PMID:35456472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9031115/
Abstract

The identification of candidate genes and genetic variations associated with growth traits is important for sheep breeding. Insulin like growth factor 1 (IGF1) and insulin like growth factor 1 receptor (IGF1R) are well-accepted candidate genes that affect animal growth and development. The current study attempted to assess the association between IGF1 and IGF1R genetic polymorphisms and growth traits in Hulun Buir sheep. To achieve this goal, we first identified three and ten single nucleotide polymorphisms (SNPs) in exons of IGF1 and IGF1R in Hulun Buir sheep and then constructed six haplotypes of IGF1R based on linkage disequilibrium, respectively. Association studies were performed between SNPs and haplotypes of IGF1 and IGF1R with twelve growth traits in a population encompassing 229 Hulun Buir sheep using a general linear model. Our result indicated three SNPs in IGF1 were significantly associated with four growth traits (p < 0.05). In IGF1R, three SNPs and two haplotype blocks were significantly associated with twelve growth traits (p < 0.05). The combined haplotype H5H5 and H5H6 in IGF1R showed the strong association with 12 superior growth traits in Hulun Buir sheep (p < 0.05). In conclusion, we identified SNPs and haplotype combinations associated with the growth traits, which provided genetic resources for marker-assisted selection (MAS) in Hulun Buir sheep breeding.

摘要

鉴定与生长性状相关的候选基因和遗传变异对于绵羊育种非常重要。胰岛素样生长因子 1（IGF1）和胰岛素样生长因子 1 受体（IGF1R）是公认的候选基因，它们影响动物的生长和发育。本研究试图评估 IGF1 和 IGF1R 遗传多态性与呼伦贝尔羊生长性状的关系。为了实现这一目标，我们首先在呼伦贝尔羊的 IGF1 和 IGF1R 外显子中鉴定了三个和十个单核苷酸多态性（SNP），然后根据连锁不平衡分别构建了 IGF1R 的六个单倍型。使用一般线性模型，在包含 229 只呼伦贝尔羊的群体中，对 IGF1 和 IGF1R 的 SNP 和单倍型与 12 个生长性状之间的关联进行了研究。结果表明，IGF1 中的三个 SNP 与四个生长性状显著相关（p<0.05）。在 IGF1R 中，三个 SNP 和两个单倍型块与 12 个生长性状显著相关（p<0.05）。IGF1R 中的组合单倍型 H5H5 和 H5H6 与呼伦贝尔羊 12 个优良生长性状具有很强的关联性（p<0.05）。总之，我们鉴定了与生长性状相关的 SNP 和单倍型组合，为呼伦贝尔羊的标记辅助选择（MAS）提供了遗传资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/c97e6b20a688/genes-13-00666-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/3857957d0674/genes-13-00666-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/ec7b5dc29478/genes-13-00666-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/7ecd7660227b/genes-13-00666-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/da4b84fcd486/genes-13-00666-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/aeea39ea4fb3/genes-13-00666-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/4653278207fe/genes-13-00666-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/c97e6b20a688/genes-13-00666-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/3857957d0674/genes-13-00666-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/ec7b5dc29478/genes-13-00666-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/7ecd7660227b/genes-13-00666-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/da4b84fcd486/genes-13-00666-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/aeea39ea4fb3/genes-13-00666-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/4653278207fe/genes-13-00666-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4227/9031115/c97e6b20a688/genes-13-00666-g007.jpg

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