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小鼠脑中两种形式的pp60c-src的发育表达。

Developmental expression of two forms of pp60c-src in mouse brain.

作者信息

Wiestler O D, Walter G

机构信息

Department of Pathology, University of California, San Diego, La Jolla 92093.

出版信息

Mol Cell Biol. 1988 Jan;8(1):502-4. doi: 10.1128/mcb.8.1.502-504.1988.

DOI:10.1128/mcb.8.1.502-504.1988
PMID:2447488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363161/
Abstract

The expression during mouse development of two forms of protein-tyrosine kinase pp60c-src, pp60 and pp60+, was investigated. At embryonic day 9 (E9), only pp60 was detected in whole-brain lysates. A trace of pp60+ was first seen at E10. In E18 embryos and in adults, pp60+ was the predominant form of pp60c-src in forebrain and midbrain lysates.

摘要

研究了两种蛋白酪氨酸激酶pp60c-src的形式，即pp60和pp60+在小鼠发育过程中的表达情况。在胚胎第9天（E9），全脑裂解物中仅检测到pp60。在E10首次发现微量的pp60+。在E18胚胎和成年小鼠中，pp60+是前脑和中脑裂解物中pp60c-src的主要形式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f6e/363161/ba0c95f29f1f/molcellb00061-0525-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f6e/363161/e9803a3f2f4e/molcellb00061-0524-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f6e/363161/ba0c95f29f1f/molcellb00061-0525-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f6e/363161/e9803a3f2f4e/molcellb00061-0524-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f6e/363161/ba0c95f29f1f/molcellb00061-0525-a.jpg

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1
Developmental expression of two forms of pp60c-src in mouse brain.小鼠脑中两种形式的pp60c-src的发育表达。
Mol Cell Biol. 1988 Jan;8(1):502-4. doi: 10.1128/mcb.8.1.502-504.1988.
2
An altered form of pp60c-src is expressed primarily in the central nervous system.一种改变形式的pp60c-src主要在中枢神经系统中表达。
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引用本文的文献

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Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM.

本文引用的文献

1
The expression in eukaryotes of a tyrosine kinase which is reactive with pp60v-src antibodies.一种与pp60v-src抗体发生反应的酪氨酸激酶在真核生物中的表达。
Differentiation. 1982;23(2):109-14. doi: 10.1111/j.1432-0436.1982.tb01273.x.
2
pp60c-src Kinase is in chick and human embryonic tissues.pp60c-src激酶存在于鸡和人类胚胎组织中。
Dev Biol. 1984 Jul;104(1):9-17. doi: 10.1016/0012-1606(84)90031-9.
3
Expression of pp60c-src protein kinase in adult and fetal human tissue: high activities in some sarcomas and mammary carcinomas.
特异性 SH3 肽配体抑制 N1-Src 激酶，揭示了 N1-Src 在 L1-CAM 诱导的神经突伸长中的作用。
Sci Rep. 2017 Feb 21;7:43106. doi: 10.1038/srep43106.
4
The hypophyseal pars tuberalis is enriched with distinct phosphotyrosine-containing proteins not detected in other areas of the brain and pituitary.垂体结节部富含在脑和垂体其他区域未检测到的独特含磷酸酪氨酸蛋白。
Cell Tissue Res. 1993 Jun;272(3):499-507. doi: 10.1007/BF00318556.
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The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src.蛋白激酶C的磷酸化位点和完整的SH2结构域对于过表达c-src的细胞中对β-肾上腺素能激动剂增强的反应是必需的。
Mol Cell Biol. 1993 Apr;13(4):2391-400. doi: 10.1128/mcb.13.4.2391-2400.1993.
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Evolutionary expression of the neuronal form of the src protein in the brain.src蛋白神经元形式在大脑中的进化表达。
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4751-5. doi: 10.1073/pnas.86.12.4751.
7
Expression of proto-oncogene products during drug-induced differentiation of a neuroblastoma cell line SK-N-DZ.原癌基因产物在药物诱导神经母细胞瘤细胞系SK-N-DZ分化过程中的表达
Acta Neuropathol. 1989;79(2):217-21. doi: 10.1007/BF00294382.
8
pp60c-src expression in the developing rat brain.发育中大鼠大脑中的pp60c-src表达。
Proc Natl Acad Sci U S A. 1988 May;85(10):3348-52. doi: 10.1073/pnas.85.10.3348.
9
Early activation of endogenous pp60src kinase activity during neuronal differentiation of cultured human neuroblastoma cells.培养的人神经母细胞瘤细胞神经元分化过程中内源性pp60src激酶活性的早期激活。
Mol Cell Biol. 1990 Jan;10(1):361-70. doi: 10.1128/mcb.10.1.361-370.1990.
10
Location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor.通过免疫细胞化学方法在大鼠前脑中对含磷酸酪氨酸蛋白的定位与胰岛素受体的分布相对应。
Proc Natl Acad Sci U S A. 1990 Jun;87(12):4453-7. doi: 10.1073/pnas.87.12.4453.
pp60c-src蛋白激酶在成人及胎儿人体组织中的表达：在某些肉瘤和乳腺癌中活性较高。
Cancer Res. 1983 Apr;43(4):1696-702.
4
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses.识别禽肉瘤病毒转化蛋白的单克隆抗体的分离
J Virol. 1983 Nov;48(2):352-60. doi: 10.1128/JVI.48.2.352-360.1983.
5
Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin.针对劳氏肉瘤病毒pp60src的单克隆抗体可与源自禽类和哺乳动物的具有酶活性的细胞pp60src发生反应。
J Virol. 1984 Aug;51(2):272-82. doi: 10.1128/JVI.51.2.272-282.1984.
6
pp60c-src is developmentally regulated in the neural retina.
Cell. 1984 Feb;36(2):249-57. doi: 10.1016/0092-8674(84)90218-6.
7
Neural tissues express high levels of the cellular src gene product pp60c-src.神经组织中细胞源基因产物pp60c-src表达水平很高。
Mol Cell Biol. 1983 Jun;3(6):1157-62. doi: 10.1128/mcb.3.6.1157-1162.1983.
8
An early developmental phase of pp60c-src expression in the neural ectoderm.神经外胚层中pp60c-src表达的早期发育阶段。
Dev Biol. 1986 Sep;117(1):83-9. doi: 10.1016/0012-1606(86)90350-7.
9
pp60c-src is expressed in human fetal and adult brain.pp60c-src在人类胎儿和成人的大脑中表达。
Am J Pathol. 1985 Apr;119(1):151-7.
10
An altered form of pp60c-src is expressed primarily in the central nervous system.一种改变形式的pp60c-src主要在中枢神经系统中表达。
Mol Cell Biol. 1987 Nov;7(11):4115-7. doi: 10.1128/mcb.7.11.4115-4117.1987.