印度脑炎相关肠病毒的分子流行病学研究。
Molecular epidemiological study of enteroviruses associated with encephalitis in children from India.
机构信息
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
出版信息
J Clin Microbiol. 2012 Nov;50(11):3509-12. doi: 10.1128/JCM.01483-12. Epub 2012 Aug 15.
Abstract
Enteroviruses have been reported in encephalitis cases. However, clinical and epidemiological characteristics of enteroviruses in encephalitis are not fully established. We prospectively investigated 204 children with encephalitis over a period of 2 years (2009 to 2010) for enterovirus. Enterovirus was detected in 45 specimens (22.1%); of these, 40 were typed by seminested reverse transcription-PCR (RT-PCR) and sequencing of the VP1 gene. Molecular typing of enterovirus revealed the predominance of echovirus 21 associated with an epidemic during the rainy seasons of 2010 and the circulation of echovirus 1, coxsackievirus B1, enterovirus 75, enterovirus 76, coxsackievirus B5, and echovirus 19. The nucleotide divergence among echovirus 21 strains was 0 to 2% at the nucleotide level. This study suggests that enterovirus is an important cause of encephalitis in children from India. To our knowledge, this is the first report of echovirus 21 in encephalitis cases worldwide.
摘要
肠道病毒已在脑炎病例中报告。然而，肠道病毒在脑炎中的临床和流行病学特征尚未完全确定。我们前瞻性地研究了 204 例在 2 年期间（2009 年至 2010 年）发生的脑炎患儿的肠道病毒。在 45 份标本中检测到肠道病毒（22.1%）；其中，40 份通过半巢式逆转录-PCR（RT-PCR）和 VP1 基因测序进行了分型。肠道病毒的分子分型显示，与 2010 年雨季流行有关的肠病毒 21 占优势，并且还存在肠病毒 1、柯萨奇病毒 B1、肠道病毒 75、肠道病毒 76、柯萨奇病毒 B5 和肠病毒 19 的循环。肠病毒 21 株之间的核苷酸差异在核苷酸水平为 0 至 2%。本研究表明，肠道病毒是印度儿童脑炎的重要病因。据我们所知，这是全球首例报告肠病毒 21 在脑炎病例中的发现。
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