Kamphuis M H, Geerlings M I, Grobbee D E, Kromhout D
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Eur J Clin Nutr. 2008 Aug;62(8):939-45. doi: 10.1038/sj.ejcn.1602804. Epub 2007 May 30.
Low B-vitamin status and high levels of serum homocysteine are found in depressed inpatients, but results of population-based studies of this association are inconclusive. We investigated whether a low dietary intake of B(6-9-12) vitamins and high levels of serum homocysteine are associated with depressive symptoms in elderly men.
The study sample included a total of 332 men aged 70-90 years who were free from cardiovascular diseases and diabetes at baseline in 1990. Depressive symptoms were measured with the Zung Self-rating Depression Scale at baseline in 1990 and dietary factors with the crosscheck dietary history method in 1985 and 1990. Serum levels of homocysteine were obtained in 1985. Multiple linear and logistic regression analyses were performed.
Dietary intake of folate (-1.19, 95% CI -2.03; -0.36) and vitamin B(6) (-2.09, 95% CI -2.92; -1.26) per standard deviation increase was associated with lower levels of serum homocysteine, while vitamin B(12) was not associated with serum homocysteine. Intake of folate, vitamin B(6), vitamin B(12) and levels of serum homocysteine were not related to depressive symptoms.
Our results do not support the hypothesis that a low dietary intake of B(6-9-12) vitamins and high levels of serum homocysteine are related to depression in healthy elderly men.
在抑郁症住院患者中发现维生素B水平低和血清同型半胱氨酸水平高，但基于人群的该关联研究结果尚无定论。我们调查了老年男性膳食中维生素B（6、9、12）摄入量低和血清同型半胱氨酸水平高是否与抑郁症状相关。
研究样本共包括332名年龄在70 - 90岁的男性，他们在1990年基线时无心血管疾病和糖尿病。1990年基线时用zung自评抑郁量表测量抑郁症状，1985年和1990年用交叉核对饮食史方法测量饮食因素。1985年检测血清同型半胱氨酸水平。进行多元线性和逻辑回归分析。
每标准差增加的叶酸（-1.19，95%可信区间-2.03；-0.36）和维生素B6（-2.09，95%可信区间-2.92；-1.26）膳食摄入量与较低的血清同型半胱氨酸水平相关，而维生素B12与血清同型半胱氨酸无关。叶酸、维生素B6、维生素B12的摄入量和血清同型半胱氨酸水平与抑郁症状无关。
我们的结果不支持以下假设，即健康老年男性膳食中维生素B（6、9、12）摄入量低和血清同型半胱氨酸水平高与抑郁症有关。
