Emergency Department, Central General Hospital, Bolzano-Bozen, Italy.
Neurology Department, Central General Hospital, Bolzano-Bozen, Italy.
Korean J Pain. 2014 Jan;27(1):49-53. doi: 10.3344/kjp.2014.27.1.49. Epub 2013 Dec 31.
The carpal tunnel syndrome (CTS) is the most common cause of severe hand pain. In this study we treated acute pain in CTS patients by means of local intradermal injections of anti-inflammatory drugs (mesotherapy).
In twenty-five patients (forty-five hands), CTS diagnosis was confirmed by clinical and neurophysiological examination prior to mesotherapy. A mixture containing lidocaine 10 mg, ketoprophen lysine-acetylsalycilate 80 mg, xantinol nicotinate 100 mg, cyanocobalamine 1,000 mcg plus injectable water was used. Sites of injection were three parallel lines above the transverse carpal ligament and two v-shaped lines, one at the base of the thenar eminence, and the other at the base of the hypothenar eminence.
The day after the treatment, all but four patients reported a significant reduction in pain and paresthesias. After 12 months, 17 patients had a complete pain relief, eight patients reported recurrence of pain and sensory symptoms and four out of them underwent surgical treatment.
With the obvious limits of a small-size open-label study, our results suggest that mesotherapy can temporary relieve pain and paresthesias in most CTS patients and in some cases its effect seems to be long-lasting. Further controlled studies are needed to confirm our preliminary findings and to compare mesotherapy to conventional approaches for the treatment of CTS.
腕管综合征（CTS）是引起严重手部疼痛的最常见原因。在这项研究中，我们通过局部皮内注射抗炎药物（间充质疗法）来治疗 CTS 患者的急性疼痛。
在二十五名患者（四十五只手）中，在接受间充质疗法之前，通过临床和神经生理学检查确认 CTS 诊断。使用含有 10 毫克利多卡因、80 毫克酮洛芬赖氨酸乙酰水杨酸、100 毫克烟酰胺、1000 微克氰钴胺素和可注射水的混合物。注射部位为腕横韧带上方的三条平行线和两条 V 形线，一条在鱼际隆起的基部，另一条在小鱼际隆起的基部。
治疗后一天，除四名患者外，其余患者均报告疼痛和感觉异常明显减轻。12 个月后，17 名患者完全缓解疼痛，8 名患者报告疼痛和感觉症状复发，其中 4 名患者接受了手术治疗。
尽管这项小规模开放性研究存在明显的局限性，但我们的结果表明，间充质疗法可暂时缓解大多数 CTS 患者的疼痛和感觉异常，在某些情况下，其效果似乎持久。需要进一步的对照研究来证实我们的初步发现，并将间充质疗法与 CTS 的常规治疗方法进行比较。
