The Italian Society of Mesotherapy, Rome, Italy.
Evid Based Complement Alternat Med. 2012;2012:436959. doi: 10.1155/2012/436959. Epub 2012 May 13.
Mesotherapy is the injection of active substances into the surface layer of the skin. This method allows a slower spread, higher levels, and longer lasting effects of drugs in the tissues underlying the site of injection (skin, muscle, and joint) compared with those following intramuscular injection. This technique is useful when a local pharmacological effect is required and relatively high doses of drug in the systemic circulation are not. Mesotherapy should only be undertaken following a complete clinical workup and subsequent diagnosis. Encouraging results have been reported in randomized, controlled clinical trials and in observational studies involving patients with various forms of musculoskeletal pain. Recommendations by experts from the Italian Society of Mesotherapy for appropriate use of mesotherapy in musculoskeletal pain and an algorithm for treating localized painful conditions are provided.
中胚层疗法是将活性物质注射到皮肤的表层。与肌肉内注射相比，该方法可使注射部位（皮肤、肌肉和关节）下方组织中的药物扩散更缓慢、浓度更高、持续时间更长。当需要局部药理作用且全身循环中不需要相对较高剂量的药物时，该技术非常有用。中胚层疗法只能在全面的临床检查和随后的诊断后进行。随机对照临床试验和涉及各种形式肌肉骨骼疼痛患者的观察性研究报告了令人鼓舞的结果。意大利中胚层疗法学会的专家提供了关于在肌肉骨骼疼痛中适当使用中胚层疗法的建议以及治疗局部疼痛疾病的算法。
