Papalia R, Zampogna B, Torre G, Lanotte A, Vasta S, Albo E, Tecame A, Denaro V
Department of Orthopaedic and Trauma Surgery, Campus Biomedico University of Rome, Via Alvaro del Portillo, Rome, Italy,
Musculoskelet Surg. 2014 Jun;98(1):9-14. doi: 10.1007/s12306-014-0311-6. Epub 2014 Jan 31.
The aim of this review is to evaluate the clinical role of sarcopenia in patients affected by osteoarthritis (OA) of major joints.
An online database research was performed, in order to retrieve all articles investigating the relationship between sarcopenia and OA. No peer-reviewed journal was excluded. Papers in English, French, Spanish and Italian language were considered. After consulting the full-text article, five studies have been included in the review.
Of the five studies included, four are prospective studies and only one is a cross-sectional study which retrieved data retrospectively. A total of 4,231 patients, presenting a mean age of 62.0 years, were studied. Three studies evaluated only female subjects. Weight, height and body mass index were reported in all the articles. Knee OA has been assessed using the Kellgren-Lawrence grading system and the American college of rheumatology criteria. Alterations of the lean body mass on body weight ratio have been reported to be as a significant predictive parameter in two studies. Relationship between radiographic OA and an increase in the leg lean mass has been observed in one study.
We cannot support neither the thesis of a direct effect of sarcopenia on OA development nor the opposite relation, because the up-to-date literature lacks basic science studies concerning these topics. The absence of clinical studies regarding measurements and tools to compare sarcopenia and OA do not allow to definitely clarify this relationship.
本综述旨在评估肌肉减少症在主要关节骨关节炎（OA）患者中的临床作用。
进行了在线数据库检索，以检索所有研究肌肉减少症与OA之间关系的文章。不排除任何同行评审期刊。纳入了英文、法文、西班牙文和意大利文的论文。在查阅全文后，五项研究被纳入本综述。
在纳入的五项研究中，四项为前瞻性研究，只有一项是回顾性检索数据的横断面研究。共研究了4231名患者，平均年龄为62.0岁。三项研究仅评估了女性受试者。所有文章均报告了体重、身高和体重指数。使用Kellgren-Lawrence分级系统和美国风湿病学会标准评估膝关节OA。两项研究报告称，瘦体重与体重之比的改变是一个重要的预测参数。一项研究观察到影像学OA与腿部瘦体重增加之间的关系。
我们既不能支持肌肉减少症对OA发展有直接影响的论点，也不能支持相反的关系，因为最新文献缺乏关于这些主题的基础科学研究。缺乏关于比较肌肉减少症和OA的测量方法和工具的临床研究，无法明确阐明这种关系。
