Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore, 117602, Singapore.
Adv Healthc Mater. 2014 Jul;3(7):977-88. doi: 10.1002/adhm.201300627. Epub 2014 Feb 1.
As society ages, aging medical problems such as organ damage or failure among senior citizens increases, raising the demand for organ repair technologies. Synthetic materials have been developed and applied in various parts of human body to meet the biomedical needs. Hydrogels, in particular, have found extensive applications as wound healing, drug delivery and controlled release, and scaffold materials in the human body. The development of the next generation of soft hydrogel biomaterials focuses on facile synthetic methods, efficacy of treatment, and tunable multi-functionalities for applications. Supramolecular 3D entities are highly attractive materials for biomedical application. They are assembled by modules via various non-covalent bonds (hydrogen bonds, p-p stacking and/or van der Waals interactions). Biodegradable thermogels are a class of such supramolecular assembled materials. Their use as soft biomaterials and their related applications are described in this Review.
随着社会老龄化，老年人的器官损伤或衰竭等医学问题日益增多，对器官修复技术的需求也在增加。合成材料已经被开发出来并应用于人体的各个部位，以满足生物医学的需求。水凝胶，特别是在人体中作为伤口愈合、药物输送和控制释放以及支架材料方面得到了广泛的应用。下一代软质水凝胶生物材料的发展重点在于简便的合成方法、治疗效果以及可调多功能性的应用。超分子 3D 实体是一种非常有吸引力的生物医学应用材料。它们通过各种非共价键（氢键、π-π 堆积和/或范德华相互作用）由模块组装而成。可生物降解的温敏水凝胶就是这样一类超分子组装材料。本综述描述了它们作为软生物材料及其相关应用。
