Werner Y, Lindberg M, Forslind B
Department of Dermatology, Södersjukhuset, Stockholm, Sweden.
Acta Derm Venereol. 1987;67(5):385-90.
In recent years much interest has been focused on the functions of the membrane-coating granules (MCGs). These granules seem to play an essential role in the formation of the barrier of the stratum corneum by extruding their lipid-rich content into the extracellular space of the corneocytes. The dry non-eczematous skin in atopic dermatitis has been reported to have defective barrier function. In the present study a quantitative electron microscopic analysis was made of the volume of MCGs in the transition zone between the stratum granulosum and stratum corneum in dry skin of patients with atopic dermatitis. The relative volume of MCGs was significantly greater than that in normal skin. This finding may indicate a disturbance of the "maturation" of the MCGs, leading to a defect in the barrier function in atopic dermatitis.
近年来，人们对膜被颗粒（MCGs）的功能给予了极大关注。这些颗粒似乎通过将富含脂质的内容物挤出到角质形成细胞的细胞外空间，在角质层屏障的形成中发挥着重要作用。据报道，特应性皮炎患者的干性非湿疹性皮肤存在屏障功能缺陷。在本研究中，对特应性皮炎患者干性皮肤颗粒层和角质层之间过渡区的MCGs体积进行了定量电子显微镜分析。MCGs的相对体积显著大于正常皮肤。这一发现可能表明MCGs的“成熟”受到干扰，导致特应性皮炎患者的屏障功能缺陷。
