糖尿病会抑制血液透析引起的泪液分泌增加。
Diabetes mellitus suppresses hemodialysis-induced increases in tear fluid secretion.
作者信息
Nakata Motoko, Okada Yuka, Kobata Hirotsugu, Shigematsu Takashi, Reinach Peter S, Tomoyose Katsuo, Saika Shizuya
机构信息
Department of Ophthalmology, Kihoku Bun-in Hospital, Wakayama Medical University School of Medicine, 219 Myouji, Katsuragicho, Wakayama 649-7113, Itogun, Japan.
出版信息
BMC Res Notes. 2014 Feb 4;7:78. doi: 10.1186/1756-0500-7-78.
BACKGROUND
Hemodialysis is essential for the survival of patients suffering from chronic renal failure. However, in diabetics the incidence of dry eye disease is higher than in non-diabetic individuals. Accordingly, we evaluated if this difference is attributable to different effects of hemodialysis on basal tear fluid secretion.
METHODS
A modified Schirmer's eye test determined if hemodialysis improved basal tear secretion rates in 36 diabetic and non-diabetic patients undergoing hemodialysis.
RESULTS
Basal tear secretion was invariant in diabetic patients whereas in non-diabetic individuals this process increased.
CONCLUSION
In non-diabetic patients, autonomic neuropathy appears to be less severe and somewhat reversible since only in these individuals hemodialysis improved basal tear fluid secretion. This difference may be a factor contributing to the lower incidence of dry eye disease in non-diabetic patients.
背景
血液透析对于慢性肾衰竭患者的生存至关重要。然而，糖尿病患者中干眼症的发病率高于非糖尿病个体。因此，我们评估了这种差异是否归因于血液透析对基础泪液分泌的不同影响。
方法
采用改良的Schirmer眼试验来确定血液透析是否能改善36例接受血液透析的糖尿病和非糖尿病患者的基础泪液分泌率。
结果
糖尿病患者的基础泪液分泌不变，而非糖尿病个体的这一过程有所增加。
结论
在非糖尿病患者中，自主神经病变似乎不太严重且在一定程度上是可逆的，因为只有这些个体的血液透析改善了基础泪液分泌。这种差异可能是导致非糖尿病患者干眼症发病率较低的一个因素。
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