Nimitphong Hataikarn, Holick Michael F
Department of Medicine; Ramathibodi Hospital; Mahidol University; Bangkok, Thailand.
Department of Medicine; Section of Endocrinology, Nutrition and Diabetes; Vitamin D, Skin and Bone Research Laboratory; Boston University Medical Center; Boston, MA USA.
Dermatoendocrinol. 2013 Jan 1;5(1):34-7. doi: 10.4161/derm.24054.
Vitamin D deficiency is more common in South Asia and Southeast Asia than is appreciated. Most studies defined 25-hydroxyvitamin D levels [25(OH)D] levels of less than 50 nmol/L (20 ng/mL) as vitamin D deficiency. With this cut-off level, the prevalence of vitamin D deficiency was about 70% or higher in South Asia and varied from 6-70% in Southeast Asia. The determinants for the variation of vitamin D status are skin pigmentation, aging, the sun protection behaviors such as application of a sunscreen, religious, lifestyle and nutritional differences. Advanced age is a known risk factor for vitamin D deficiency. Interestingly, elderly in countries such as Korea and Thailand, had higher 25(OH)D levels when compared with young people. This widespread vitamin D deficiency problem especially in the young generation is an urgent health issue that needs to be remedied.
维生素D缺乏症在南亚和东南亚比人们所认识到的更为普遍。大多数研究将25-羟基维生素D[25(OH)D]水平低于50纳摩尔/升(20纳克/毫升)定义为维生素D缺乏。按照这个临界值,南亚维生素D缺乏症的患病率约为70%或更高,而在东南亚则在6%-70%之间。维生素D状况变化的决定因素包括皮肤色素沉着、衰老、防晒行为(如涂抹防晒霜)、宗教、生活方式和营养差异。高龄是维生素D缺乏症的一个已知风险因素。有趣的是,与年轻人相比,韩国和泰国等国的老年人25(OH)D水平更高。这种广泛存在的维生素D缺乏问题,尤其是在年轻一代中,是一个亟待解决的紧迫健康问题。