Huang Yung-Kai, Lee Wei-Fang, Wang Meng-Jiy, Chang Yus-Han Sophie, Tchaou Wen-Shiun, Chang Wei-Jen, Lee Sheng-Yang, Sheu Joen-Rong, Teng Nai-Chia
School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
PLoS One. 2014 Jan 30;9(1):e87100. doi: 10.1371/journal.pone.0087100. eCollection 2014.
Our goal was to investigate the relationship between clinical status and the presence of carious or periodontal pathogens among parent-child familial pairs. Clinical practices of risk assessment with consideration of familial pathogen interaction might reduce the need for therapy, improve patient outcomes, and ultimately reduce oral disease burden.
In this study, we enrolled 30 parent-child pairs, with the children exhibiting complete deciduous dentition or mixed dentition with only permanent first molars. Clinical statuses were evaluated using caries and periodontal disease indicators, including the sum of decay and the number of missing or filled teeth (DMFT) for adults, decay, extraction caused by dental disease, and filled teeth (deft), for children, probing depth, and plaque control record (PCR). Supra- and sub-gingival bacteria were determined based on semi-quantitative measurements of microbial infection by using data from the Dentocult(®) SM test (caries-related organisms) and the PerioCheck(®) test (periodontal disease-related organisms).
No statistically significant relationship was detected between the prevalence of periodontal pathogens and that of cariogenic pathogens in the oral cavity. However, the clinical status of caries (DMFT) was negatively correlated with the clinical status of periodontal disease (pocket depth) in parents who were infected with dominant periodontal pathogens (r = -0.59, p<0.01). Parents' DMFT scores were positively correlated with children's deft and PCR scores. PCR and deft scores of children appeared to decrease significantly with the parent's pocket depth.
The study showed that the quantity of caries pathogens were not significant related to periodontal pathogens, but the caries clinical outcome is negative related with periodontal clinical outcome between familial pairs.
我们的目标是研究亲子家庭对中临床状况与龋病或牙周病原体存在之间的关系。考虑家族病原体相互作用的风险评估临床实践可能会减少治疗需求，改善患者预后，并最终减轻口腔疾病负担。
在本研究中，我们招募了30对亲子对，其中儿童表现为乳牙列完整或仅第一恒磨牙的混合牙列。使用龋病和牙周疾病指标评估临床状况，包括成人的龋坏、缺失或充填牙数总和（DMFT），儿童的龋坏、因牙病导致的拔牙和充填牙数（deft）、探诊深度和菌斑控制记录（PCR）。根据使用Dentocult(®) SM试验（与龋病相关的微生物）和PerioCheck(®)试验（与牙周疾病相关的微生物）的数据对微生物感染进行半定量测量来确定龈上和龈下细菌。
未检测到口腔中牙周病原体患病率与致龋病原体患病率之间存在统计学上的显著关系。然而，在感染主要牙周病原体的父母中，龋病的临床状况（DMFT）与牙周疾病的临床状况（牙周袋深度）呈负相关（r = -0.59，p<0.01）。父母的DMFT评分与儿童的deft和PCR评分呈正相关。儿童的PCR和deft评分似乎随着父母的牙周袋深度而显著降低。
该研究表明，龋病病原体数量与牙周病原体无显著相关性，但在家族对中龋病临床结果与牙周临床结果呈负相关。
