van Baarlen J, Schuurman H J, van Unnik J A
Institute for Pathology, University Hospital, Utrecht, The Netherlands.
Cancer. 1988 Apr 1;61(7):1371-6. doi: 10.1002/1097-0142(19880401)61:7<1371::aid-cncr2820610716>3.0.co;2-g.
Multilobated non-Hodgkin's lymphomas (NHL) have recently been recognized as an NHL variant. During a period of 10 years we observed 30 individuals with NHL in which more than 30% of the malignant cells had a characteristic multilobation. The immunologic phenotype was determined in 14 of these cases. One was of T-cell lineage, and the others exhibited B-lymphoid markers. Sixty-eight percent of the patients presented with extranodal localizations. In the clinical follow-up a complete remission was observed in 78% of patients with a mean duration of 37 months (range, 5 to 120 months). The actuarial survival after 5 years was 45%. From these data we conclude that multilobated NHL are comparable to diffuse, large cleaved-cell NHL of an intermediate grade malignancy according to the Working Formulation or are comparable to the diffuse centrocytic-centroblastic NHL according to the Kiel classification. The neoplastic cells are to be considered as variants of follicle center cells, but the clinicopathologic correlation indicates that multilobated NHL represent a distinct nosologic entity.
多叶性非霍奇金淋巴瘤（NHL）最近被确认为NHL的一种变体。在10年期间，我们观察了30例NHL患者，其中超过30%的恶性细胞具有特征性的多叶性。对其中14例病例进行了免疫表型测定。1例为T细胞谱系，其他病例表现为B淋巴细胞标志物。68%的患者出现结外定位。在临床随访中，78%的患者达到完全缓解，平均缓解持续时间为37个月（范围为5至120个月）。5年后的精算生存率为45%。根据这些数据，我们得出结论，多叶性NHL根据工作分类法与中度恶性的弥漫性大裂细胞NHL相当，或根据基尔分类法与弥漫性中心细胞-中心母细胞NHL相当。肿瘤细胞应被视为滤泡中心细胞的变体，但临床病理相关性表明多叶性NHL代表一种独特的疾病实体。
