多叶状B细胞淋巴瘤，中心母细胞淋巴瘤的一种变异型。四例报告。

Multilobated B-cell lymphoma, a variant of centroblastic lymphoma. Report of four cases.

作者信息

Chan J K, Ng C S, Tung S

出版信息

Histopathology. 1986 Jun;10(6):601-12. doi: 10.1111/j.1365-2559.1986.tb02513.x.

DOI:10.1111/j.1365-2559.1986.tb02513.x

Abstract

Four cases of multilobated B-cell lymphoma, one follicular and three diffuse, are described. Many of the lymphoma cells show marked lobulation of the nuclei, and possess multiple prominent nucleoli. There are admixed classical centrocytes, classical centroblasts, and cells with morphology intermediate between classical centroblasts and multilobated cells. Multilobated cells are also observed in small numbers in germinal centres of lymph nodes showing reactive follicular hyperplasia. We believe that the multilobated B-cell may represent one form of centroblast during transition between the centroblastic and centrocytic stages. Multilobated B-cell lymphoma may be its neoplastic counterpart in which the nuclear lobulation is further exaggerated.

摘要

本文描述了4例多叶状B细胞淋巴瘤，其中1例为滤泡性，3例为弥漫性。许多淋巴瘤细胞显示细胞核有明显的分叶，并具有多个显著的核仁。混有典型的中心细胞、典型的中心母细胞以及形态介于典型中心母细胞和多叶状细胞之间的细胞。在表现为反应性滤泡增生的淋巴结生发中心也可见少量多叶状细胞。我们认为，多叶状B细胞可能代表中心母细胞向中心细胞阶段转变过程中的一种形式。多叶状B细胞淋巴瘤可能是其肿瘤对应物，其中核分叶进一步加剧。